← Back to patent-cliff list
CAS 155619-62-8
(3E)-5-[(tert-butyldimethylsilyl)oxy]-1-[(9S)-9-[(tert-butyldimethylsilyl)oxy]-6,6,8-trimethyl-1,4-dioxaspiro[4.5]dec-7-en-7-yl]-3-methylpent-3-ene-1,2-dione
Codes：(XVI)101438-15-a
Application context (from source-drug indications)
乳腺癌Paclitaxel/Encequidar mesylate腺癌Paclitaxel/Encequidar mesylate血管肉瘤Paclitaxel/Encequidar mesylate实体瘤Paclitaxel/Encequidar mesylate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Paclitaxel/Encequidar mesylatePaclitaxel/Encequidar mesylate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
6,6,8-Trimethyl-1,4-dioxaspiro[4.5]decan-7-one→6,6,8-trimethyl-1,4-dioxaspiro[4.5]dec-7-en-7-yl trifluoromethanesulfonate→7-ethenyl-6,6,8-trimethyl-1,4-dioxaspiro[4.5]dec-7-ene→tert-butyl({[(7S)-9-{2-[(tert-butyldimethylsilyl)oxy]ethyl}-8,10,10-trimethyl-1,4-dioxaspiro[4.5]dec-8-en-7-yl]oxy})dimethylsilane→2-{6,6,8-trimethyl-1,4-dioxaspiro[4.5]dec-7-en-7-yl}ethan-1-ol→tert-butyldimethyl(2-{6,6,8-trimethyl-1,4-dioxaspiro[4.5]dec-7-en-7-yl}ethoxy)silane→(3aS)-1,3,3-trimethyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole→(7S)-9-{2-[(tert-butyldimethylsilyl)oxy]ethyl}-8,10,10-trimethyl-1,4-dioxaspiro[4.5]dec-8-en-7-ol→2-[(9S)-9-[(tert-butyldimethylsilyl)oxy]-6,6,8-trimethyl-1,4-dioxaspiro[4.5]dec-7-en-7-yl]ethan-1-ol→2-[(9S)-9-[(tert-butyldimethylsilyl)oxy]-6,6,8-trimethyl-1,4-dioxaspiro[4.5]dec-7-en-7-yl]acetaldehyde→tert-butyl({[(2E)-3-iodobut-2-en-1-yl]oxy})dimethylsilane→(3E)-4-[(tert-butyldimethylsilyl)oxy]-1-[(9S)-9-[(tert-butyldimethylsilyl)oxy]-6,6,8-trimethyl-1,4-dioxaspiro[4.5]dec-7-en-7-yl]-3-methylbut-3-en-2-ol→(3E)-5-[(tert-butyldimethylsilyl)oxy]-1-[(9S)-9-[(tert-butyldimethylsilyl)oxy]-6,6,8-trimethyl-1,4-dioxaspiro[4.5]dec-7-en-7-yl]-3-methylpent-3-en-2-one→1-[(1S,2R,3S,6S)-6-(benzyloxy)-2-(hydroxymethyl)-1-methyl-4-oxo-3-[(phenylsulfanyl)methyl]cyclohexyl]-2-[(9S)-9-[(tert-butyldimethylsilyl)oxy]-6,6,8-trimethyl-1,4-dioxaspiro[4.5]dec-7-en-7-yl]ethane-1,2-dione→(3E)-5-[(tert-butyldimethylsilyl)oxy]-1-[(9S)-9-[(tert-butyldimethylsilyl)oxy]-6,6,8-trimethyl-1,4-dioxaspiro[4.5]dec-7-en-7-yl]-1-hydroxy-3-methylpent-3-en-2-one→(3E)-5-[(tert-butyldimethylsilyl)oxy]-1-[(9S)-9-[(tert-butyldimethylsilyl)oxy]-6,6,8-trimethyl-1,4-dioxaspiro[4.5]dec-7-en-7-yl]-3-methylpent-3-ene-1,2-dione→[(2Z,3E)-4-(benzyloxy)-2-[2-(phenylsulfanyl)ethylidene]but-3-en-1-yl]trimethylsilane→1-[(1S,2R,3S,6S)-6-(benzyloxy)-2-{[(tert-butyldimethylsilyl)oxy]methyl}-1-methyl-4-oxo-3-[(phenylsulfanyl)methyl]cyclohexyl]-2-[(9S)-9-[(tert-butyldimethylsilyl)oxy]-6,6,8-trimethyl-1,4-dioxaspiro[4.5]dec-7-en-7-yl]ethane-1,2-dione→(1R,2S,3S,6S)-3-(benzyloxy)-2-{2-[(9S)-9-[(tert-butyldimethylsilyl)oxy]-6,6,8-trimethyl-1,4-dioxaspiro[4.5]dec-7-en-7-yl]-2-oxoacetyl}-2-methyl-5-oxo-6-[(phenylsulfanyl)methyl]cyclohexane-1-carbaldehyde→(1R,2S,3S,6S)-3-(benzyloxy)-2-{2-[(3S)-3-hydroxy-2,6,6-trimethyl-5-oxocyclohex-1-en-1-yl]-2-oxoacetyl}-2-methyl-5-oxo-6-[(phenylsulfanyl)methyl]cyclohexane-1-carbaldehyde
Intermediates available on this site
No listed intermediates for this target yet — send an RFQ directly and it will enter our matching pool.
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.