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CAS 1559057-45-2

isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((E)-3-oxo-4-phenoxybut-1-en-1-yl)cyclopentyl)hept-5-enoate

Codes:TAFL-010

Application context (from source-drug indications)

高眼压他氟前列素开角型青光眼他氟前列素青光眼他氟前列素

Source drugs (routes using this intermediate)

DrugTierExpiry
他氟前列素TafluprostTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

他氟前列素优化路线steps: 4total yield: 20 mg
isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((E)-3-hydroxy-4-phenoxybut-1-en-1-yl)cyclopentyl)hept-5-enoate→isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((E)-3-oxo-4-phenoxybut-1-en-1-yl)cyclopentyl)hept-5-enoate→TAFL-011→tert-butyl 5-formylpyrazine-2-carboxylate→TAFL-013

Intermediates available on this site

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