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CAS 1598430-18-2
(R)-N-(4-(chlorodifluoromethoxy)phenyl)-6-(3-hydroxypyrrolidin-1-yl)-5-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-5-yl)nicotinamide
Codes: ASCIM-007
Application context (from source-drug indications)
Chronic myeloid leukaemiaAsciminib hydrochlorideAcute lymphoblastic leukaemiaAsciminib hydrochlorideMyeloid leukaemiaAsciminib hydrochlorideChronic-phase myeloid leukaemiaAsciminib hydrochloride前体B-细胞成淋巴细胞白血病-淋巴瘤Asciminib hydrochlorideHaematopoietic stem cell transplantationAsciminib hydrochloride
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Asciminib hydrochloride | Tier B — Position early | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
5-bromo-6-chloronicotinic acid→4-(chlorodifluoromethoxy)aniline→5-bromo-6-chloro-N-(4-(chlorodifluoromethoxy)phenyl)nicotinamide→(R)-pyrrolidin-3-ol→(R)-5-bromo-N-(4-(chlorodifluoromethoxy)phenyl)-6-(3-hydroxypyrrolidin-1-yl)nicotinamide→5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazole→(R)-N-(4-(chlorodifluoromethoxy)phenyl)-6-(3-hydroxypyrrolidin-1-yl)-5-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-5-yl)nicotinamide→(R)-N-(4-(chlorodifluoromethoxy)phenyl)-6-(3-hydroxypyrrolidin-1-yl)-5-(1H-pyrazol-5-yl)nicotinamide
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications | Action |
|---|---|---|---|---|---|---|
| Qualified Partner — East China API Works | (R)-3-Pyrrolidinol Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | Methyl 5-bromo-6-chloronicotinate Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | 1-(Tetrahydropyran-2-yl)-1H-pyrazole-5-boronic acid pinacol ester Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | 4-(Chlorodifluoromethoxy)aniline Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | 5-Bromo-6-chloronicotinic acid Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | 4-[chloro(difluoro)methoxy]-{N}-methylaniline Pharmaceutical Intermediates | On request | On request | On request | — |
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.