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CAS 160232-12-2
benzyl ((2R,3S)-2-hydroxy-4-phenyl-3-(((((S)-tetrahydrofuran-3-yl)oxy)carbonyl)amino)butyl)(isobutyl)carbamate
Codes: FOSAC-005
Application context (from source-drug indications)
HIV infectionFosamprenavir Calcium
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Fosamprenavir Calcium | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
tert-butyl ((2S,3R)-3-hydroxy-4-(isobutylamino)-1-phenylbutan-2-yl)carbamate→benzyl ((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutyl)(isobutyl)carbamate→benzyl ((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)(isobutyl)carbamate hydrochloride→(S)-2,5-dioxopyrrolidin-1-yl (tetrahydrofuran-3-yl) carbonate→benzyl ((2R,3S)-2-hydroxy-4-phenyl-3-(((((S)-tetrahydrofuran-3-yl)oxy)carbonyl)amino)butyl)(isobutyl)carbamate→(S)-tetrahydrofuran-3-yl ((2S,3R)-3-hydroxy-4-(isobutylamino)-1-phenylbutan-2-yl)carbamate→4-nitrobenzenesulfonyl chloride→(S)-tetrahydrofuran-3-yl ((2S,3R)-3-hydroxy-4-(N-isobutyl-4-nitrophenylsulfonamido)-1-phenylbutan-2-yl)carbamate
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