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CAS 1613271-19-4
(R)-4-((1R,2R,3aS,9aS)-2-((tert-butyldiphenylsilyl)oxy)-5-methoxy-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-1-yl)butane-1,2-diol
Codes: TREP-054
Application context (from source-drug indications)
Interstitial lung diseaseTreprostinilPulmonary hypertensionTreprostinilPulmonary arterial hypertensionTreprostinilIdiopathic pulmonary fibrosisTreprostinilPulmonary fibrosisTreprostinilIdiopathic pulmonary arterial hypertensionTreprostinil
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Treprostinil | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
methyl 2-bromoacetate→(1R,2R,3aS,9aS)-1-((S)-3-hydroxyoctyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalene-2,5-diol→(3-methoxyphenyl)methanol→tert-butyl((3-methoxybenzyl)oxy)dimethylsilane→3-bromoprop-1-ene→((2-allyl-3-methoxybenzyl)oxy)(tert-butyl)dimethylsilane→(2-allyl-3-methoxyphenyl)methanol→2-allyl-3-methoxybenzaldehyde→(R)-5-(but-3-yn-1-yl)-2,2,3,3,8,8,9,9-octamethyl-4,7-dioxa-3,8-disiladecane→(6R)-1-(2-allyl-3-methoxyphenyl)-6,7-bis((tert-butyldimethylsilyl)oxy)hept-2-yn-1-ol→(R)-1-(2-allyl-3-methoxyphenyl)-6,7-bis((tert-butyldimethylsilyl)oxy)hept-2-yn-1-one→(R)-1-methyl-3,3-diphenylhexahydropyrrolo[1,2-c][1,3,2]oxazaborole→(1S,6R)-1-(2-allyl-3-methoxyphenyl)-6,7-bis((tert-butyldimethylsilyl)oxy)hept-2-yn-1-ol→(5S,10R)-5-(2-allyl-3-methoxyphenyl)-10-((tert-butyldimethylsilyl)oxy)-2,2,3,3,13,13,14,14-octamethyl-4,12-dioxa-3,13-disilapentadec-6-yne→(4R,9aS)-3-((R)-3,4-bis((tert-butyldimethylsilyl)oxy)butyl)-4-((tert-butyldimethylsilyl)oxy)-8-methoxy-1,4,9,9a-tetrahydro-2H-cyclopenta[b]naphthalen-2-one→(3aS,9aS)-1-((R)-3,4-bis((tert-butyldimethylsilyl)oxy)butyl)-5-methoxy-1,3,3a,4,9,9a-hexahydro-2H-cyclopenta[b]naphthalen-2-one→(1R,2R,3aS,9aS)-1-((R)-3,4-bis((tert-butyldimethylsilyl)oxy)butyl)-5-methoxy-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-2-ol→(R)-5-(2-((1R,2R,3aS,9aS)-2-((tert-butyldiphenylsilyl)oxy)-5-methoxy-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-1-yl)ethyl)-2,2,3,3,8,8,9,9-octamethyl-4,7-dioxa-3,8-disiladecane→(R)-4-((1R,2R,3aS,9aS)-2-((tert-butyldiphenylsilyl)oxy)-5-methoxy-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-1-yl)butane-1,2-diol→TREP-055→tert-butyl(((1R,2R,3aS,9aS)-5-methoxy-1-(2-((R)-oxiran-2-yl)ethyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-2-yl)oxy)diphenylsilane→(S)-1-((1R,2R,3aS,9aS)-2-((tert-butyldiphenylsilyl)oxy)-5-methoxy-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-1-yl)octan-3-ol→(1R,2R,3aS,9aS)-2-((tert-butyldiphenylsilyl)oxy)-1-((S)-3-hydroxyoctyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-5-ol→ethyl 2-(((1R,2R,3aS,9aS)-2-hydroxy-1-((S)-3-hydroxyoctyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-5-yl)oxy)acetate→(S)-oxiran-2-ylmethanol→(R)-tert-butyldimethyl(oxiran-2-ylmethoxy)silane→trimethyl(prop-1-yn-1-yl)silane→(R)-1-((tert-butyldimethylsilyl)oxy)-6-(trimethylsilyl)hex-5-yn-2-ol→(R)-1-((tert-butyldimethylsilyl)oxy)hex-5-yn-2-ol
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications |
|---|---|---|---|---|---|
| Qualified Partner — East China API Works | (1R,2R,3aS,9aS)-2,3,3a,4,9,9a-Hexahydro-1-[(3S)-3-hydroxyoctyl]-1H-benz[f]indene-2,5-diol Pharmaceutical Intermediates | On request | On request | On request | — |
| Unibest Nantong cGMP Site | 1-broMo-5-fluoro-2-Methyl-3-nitrobenzene Pharmaceutical Intermediates | On request | On request | On request | — |
| Unibest Taizhou GMP-like Site | methyl 4-cyclopropyl-2-fluorobenzoate Pharmaceutical Intermediates | On request | On request | On request | — |
| Qualified Partner — East China API Works | tert-butyl 2-(4-amino-6-chloropyrimidin-5-yloxy)ethylmethylcarbamate Pharmaceutical Intermediates | On request | On request | On request | — |
| Unibest Nantong cGMP Site | 2H-Benz[f]inden-2-one, 9-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3,3a,4,9-tetrahydro-5-methoxy-1-[(3S)-3-[(tetrahydro-2H-pyran-2-yl)oxy]octyl]-, (3aS,9R)- Pharmaceutical Intermediates | On request | On request | On request | — |
| Unibest Taizhou GMP-like Site | 2-allyl-3-methoxybenzaldehyde Pharmaceutical Intermediates | On request | On request | On request | — |
| Qualified Partner — East China API Works | (5S)-1-Decyn-5-ol Pharmaceutical Intermediates | On request | On request | On request | — |
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.