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CAS 16466-97-0
prop-1-yn-1-ylmagnesium bromide
Codes: ORLI-025
Application context (from source-drug indications)
ObesityOrlistatI型高脂蛋白血症OrlistatHypertriglyceridaemiaOrlistat女性不孕OrlistatDiabetesOrlistatObstructive sleep apnoea syndromeOrlistat
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Orlistat | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
ethyl dodecanoate→N,O-dimethylhydroxylamine hydrochloride→N-methoxy-N-methyldodecanamide→prop-1-yn-1-ylmagnesium bromide→pentadec-2-yn-4-one→(S)-pentadec-2-yn-4-ol→(S)-pentadec-1-yn-4-ol→(S)-tert-butyldimethyl(pentadec-1-yn-4-yloxy)silane→1-iodohexane→(S)-tert-butyl(henicos-7-yn-10-yloxy)dimethylsilane→(S)-henicos-7-yn-10-ol→(S,Z)-henicos-7-en-10-ol→(S)-1-((2S,3R)-3-hexyloxiran-2-yl)tridecan-2-ol→(2R,3S)-2-hexyl-3-((S)-2-(methoxymethoxy)tridecyl)oxirane→(3S,4S)-3-hexyl-4-((S)-2-(methoxymethoxy)tridecyl)oxetan-2-one→ethane-1,2-dithiol→(3S,4S)-3-hexyl-4-((S)-2-hydroxytridecyl)oxetan-2-one→(S)-2-(((benzyloxy)carbonyl)amino)-4-methylpentanoic acid→(S)-(S)-1-((2S,3S)-3-hexyl-4-oxooxetan-2-yl)tridecan-2-yl 2-(((benzyloxy)carbonyl)amino)-4-methylpentanoate→acetic formic anhydride
Intermediates available on this site
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