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CAS 1703754-98-6
1-((1R,2R)-2-(pent-4-en-1-yl)cyclopropyl)ethan-1-one
Codes：GRAZ-043
Application context (from source-drug indications)
丙型肝炎Grazoprevir HydrateHIV感染Grazoprevir Hydrate慢性丙型肝炎Grazoprevir Hydrate肾功能不全Grazoprevir Hydrate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Grazoprevir HydrateGrazoprevir Hydrate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(R)-3,3-dimethyl-2-((((1R,2R)-2-(pent-4-en-1-yl)cyclopropoxy)carbonyl)amino)butanoic acid→methyl (2S,4R)-4-((3-chloro-7-methoxyquinoxalin-2-yl)oxy)-1-((S)-3,3-dimethyl-2-((((1R,2R)-2-(pent-4-en-1-yl)cyclopropoxy)carbonyl)amino)butanoyl)pyrrolidine-2-carboxylate→methyl (33R,35S,91R,92R,5S,E)-5-(tert-butyl)-17-methoxy-4,7-dioxo-2,8-dioxa-6-aza-1(2,3)-quinoxalina-3(3,1)-pyrrolidina-9(1,2)-cyclopropanacyclotetradecaphan-13-ene-35-carboxylate→(1R,2R)-2-(pent-4-en-1-yl)cyclopropan-1-ol→1-((1R,2R)-2-(pent-4-en-1-yl)cyclopropyl)ethan-1-one→methyl (2S,4R)-4-((3-chloro-7-methoxyquinoxalin-2-yl)oxy)pyrrolidine-2-carboxylate methanesulfonate→sodium pivalate
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