← Back to patent-cliff list
CAS 1809015-77-7
3-[(3-Amino-4-fluorophenyl)(hydroxy)methyl]benzonitrile
Codes: Berotralstat-003
Application context (from source-drug indications)
遗传性血管性水肿Berotralstat
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Berotralstat | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
[3-[Bis(trimethylsilyl)amino]-4-fluorophenyl](bromido)magnesium→3-Formylbenzonitrile→3-[(3-Amino-4-fluorophenyl)(hydroxy)methyl]benzonitrile→1-(3-[[(tert-Butoxycarbonyl)amino]methyl]phenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid→tert-Butyl ([3-[5-([5-[(3-cyanophenyl)(hydroxy)methyl]-2-fluorophenyl]carbamoyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]methyl)carbamate→Cyclopropylmethanamine→tert-Butyl [(3-[5-[(5-[(3-cyanophenyl)[(cyclopropylmethyl)amino]methyl]-2-fluorophenyl)carbamoyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl)methyl]carbamate→1-[3-(Aminomethyl)phenyl]-N-(5-[(3-cyanophenyl)[(cyclopropylmethyl)amino]methyl]-2-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide→1-[3-(Aminomethyl)phenyl]-N-(5-[(R)-(3-cyanophenyl)[(cyclopropylmethyl)amino]methyl]-2-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide
Intermediates available on this site
No listed intermediates for this target yet — send an RFQ directly and it will enter our matching pool.
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.