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CAS 1809020-38-9
(SR)-N-[(R)-(3-Amino-4-fluorophenyl)(3-cyanophenyl)methyl]-2-methylpropane-2-sulfinamide
Codes: Berotralstat-018
Application context (from source-drug indications)
遗传性血管性水肿Berotralstat
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Berotralstat | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
5-Bromo-2-fluoroaniline→N-(5-Bromo-2-fluorophenyl)-1,1,1-trimethyl-N-(trimethylsilyl)silanamine→[3-[Bis(trimethylsilyl)amino]-4-fluorophenyl](bromido)magnesium→3-Formylbenzonitrile→(SR)-N-[(3-Cyanophenyl)methylidene]-2-methylpropane-2-sulfinamide→(SR)-N-[(R)-(3-Amino-4-fluorophenyl)(3-cyanophenyl)methyl]-2-methylpropane-2-sulfinamide→3-[(R)-Amino(3-amino-4-fluorophenyl)methyl]benzonitrile hydrogen chloride→Cyclopropanal→Oxalic acid 3-[(R)-(3-amino-4-fluorophenyl)[(cyclopropylmethyl)amino]methyl]benzonitrile→1-(3-[[(tert-Butoxycarbonyl)amino]methyl]phenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid→tert-Butyl [(3-[5-[(5-[(R)-(3-cyanophenyl)[(cyclopropylmethyl)amino]methyl]-2-fluorophenyl)carbamoyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl)methyl]carbamate
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