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CAS 1825379-70-1

(2S,3S,4R,5R,6R)-2-(3-(benzo[b]thiophen-2-ylmethyl)-4-fluorophenyl)-4,5-bis(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-3-ol

Codes:IPRA-018

Application context (from source-drug indications)

二型糖尿病磷酸西格列汀一水合物/伊格列净L-脯氨酸盐

Source drugs (routes using this intermediate)

DrugTierExpiry
磷酸西格列汀一水合物/伊格列净L-脯氨酸盐Sitagliptin Phosphate Monohydrate/Ipragliflozin L-ProlineTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

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磷酸西格列汀一水合物/伊格列净L-脯氨酸盐优化路线steps: 1total yield: 3.58 g
2-(5-bromo-2-fluorobenzyl)benzo[b]thiophene→(1S,3R,4R,5S,6R)-4,5-bis(benzyloxy)-3-((benzyloxy)methyl)-2,7-dioxabicyclo[4.1.0]heptane→(2S,3S,4R,5R,6R)-2-(3-(benzo[b]thiophen-2-ylmethyl)-4-fluorophenyl)-4,5-bis(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-3-ol

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