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CAS 186038-82-4
diethyl 2-(1-cyano-3-methylbutyl)malonate
Codes: PREG-014
Application context (from source-drug indications)
FibromyalgiaPregabalinSeizurePregabalinPostherpetic neuralgiaPregabalin神经痛PregabalinPartial-onset seizurePregabalinDiabetic neuropathyPregabalin
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Pregabalin | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
3-methylbutanal→diethyl malonate→diethyl 2-(3-methylbutylidene)malonate→diethyl 2-(1-cyano-3-methylbutyl)malonate→3-(aminomethyl)-5-methylhexanoic acid→(S)-2-(carboxymethyl)-4-methylpentan-1-aminium (S)-2-hydroxy-2-phenylacetate
diethyl 2-(1-cyano-3-methylbutyl)malonate→sodium (3S)-3-cyano-2-(ethoxycarbonyl)-5-methylhexanoate→ethyl (S)-3-cyano-5-methylhexanoate→potassium (S)-3-cyano-5-methylhexanoate
Intermediates available on this site
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