CAS 187960-90-3

(1S,2S,3S,4S,5S,9S)-5-(acetyloxy)-3-[(3R)-3-[(benzyloxy)methoxy]hexa-1,5-dien-2-yl]-1-hydroxy-4,8,11,11-tetramethyl-6-oxo-9-[(triisopropylsilyl)oxy]bicyclo[5.3.1]undec-7-en-2-yl benzoate

Codes：(XIX)101438-31-b

Application context (from source-drug indications)

乳腺癌Paclitaxel/Encequidar mesylate腺癌Paclitaxel/Encequidar mesylate血管肉瘤Paclitaxel/Encequidar mesylate实体瘤Paclitaxel/Encequidar mesylate

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Paclitaxel/Encequidar mesylatePaclitaxel/Encequidar mesylate	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Paclitaxel/Encequidar mesylate优化路线steps: 11total yield: /

(1S,2S,3S,4S,5S,9S)-5-(acetyloxy)-3-[(3R)-3-[(benzyloxy)methoxy]hexa-1,5-dien-2-yl]-1-hydroxy-4,8,11,11-tetramethyl-6-oxo-9-[(triisopropylsilyl)oxy]bicyclo[5.3.1]undec-7-en-2-yl benzoate→2-[(1S,5S,6S,7S,8S,12S)-7,11,14,14-tetramethyl-3,9-dioxo-8-[(triethylsilyl)oxy]-12-[(triisopropylsilyl)oxy]-2,4-dioxatricyclo[8.3.1.0(1,5)]tetradec-10-en-6-yl]prop-2-enal→(1S,5S,6S,7S,8S,12S)-6-[(3R)-3-[(benzyloxy)methoxy]hexa-1,5-dien-2-yl]-7,11,14,14-tetramethyl-8-[(triethylsilyl)oxy]-12-{[tris(propan-2-yl)silyl]oxy}-2,4-dioxatricyclo[8.3.1.0(1,5)]tetradec-10-ene-3,9-dione→1,3,4,6,7,8-Hexahydro-2H-pyrimido[1,2-a]pyrimidine→(1S,2S,3S,4S,6R,9S)-6-(acetyloxy)-3-[(3R)-3-[(benzyloxy)methoxy]hexa-1,5-dien-2-yl]-1-hydroxy-4,8,11,11-tetramethyl-5-oxo-9-{[tris(propan-2-yl)silyl]oxy}bicyclo[5.3.1]undec-7-en-2-yl benzoate→(1S,2S,3S,4S,6R,9S)-6-(acetyloxy)-3-[(3R)-3-[(benzyloxy)methoxy]-5-oxopent-1-en-2-yl]-1-hydroxy-4,8,11,11-tetramethyl-5-oxo-9-{[tris(propan-2-yl)silyl]oxy}bicyclo[5.3.1]undec-7-en-2-yl benzoate→(1S,2S,3R,5R,7S,8S,10R,13S)-10-(acetyloxy)-5-[(benzyloxy)methoxy]-1,7-dihydroxy-8,12,15,15-tetramethyl-4-methylidene-9-oxo-13-[(triisopropylsilyl)oxy]tricyclo[9.3.1.0(3,8)]pentadec-11-en-2-yl benzoate→(1S,2S,3R,5R,7S,8S,10R,13S)-10-(acetyloxy)-5-[(benzyloxy)methoxy]-1-hydroxy-8,12,15,15-tetramethyl-4-methylidene-9-oxo-7-{[(2,2,2-trichloroethoxy)carbonyl]oxy}-13-{[tris(propan-2-yl)silyl]oxy}tricyclo[9.3.1.0(3,8)]pentadec-11-en-2-yl benzoate→(1S,5S,6R,7S,10R,12S,13S,15R,18S)-15-(acetyloxy)-13,17,20,20-tetramethyl-3,14-dioxo-12-{[(2,2,2-trichloroethoxy)carbonyl]oxy}-18-[(triisopropylsilyl)oxy]-2,4,9-trioxapentacyclo[14.3.1.0(1,5).0(6,13).0(7,10)]icos-16-en-7-yl acetate→(1S,2S,3R,5R,7S,8S,10R,13S)-10-(acetyloxy)-1,5-dihydroxy-8,12,15,15-tetramethyl-4-methylidene-9-oxo-7-{[(2,2,2-trichloroethoxy)carbonyl]oxy}-13-[(triisopropylsilyl)oxy]tricyclo[9.3.1.0(3,8)]pentadec-11-en-2-yl benzoate→(1S,2S,3R,5R,7S,8S,10R,13S)-10-(acetyloxy)-1-hydroxy-5-(methanesulfonyloxy)-8,12,15,15-tetramethyl-4-methylidene-9-oxo-7-{[(2,2,2-trichloroethoxy)carbonyl]oxy}-13-{[tris(propan-2-yl)silyl]oxy}tricyclo[9.3.1.0(3,8)]pentadec-11-en-2-yl benzoate→(1S,2S,3S,5S,7S,8S,10R,13S)-10-(acetyloxy)-5-bromo-1-hydroxy-8,12,15,15-tetramethyl-4-methylidene-9-oxo-7-{[(2,2,2-trichloroethoxy)carbonyl]oxy}-13-[(triisopropylsilyl)oxy]tricyclo[9.3.1.0(3,8)]pentadec-11-en-2-yl benzoate→(1S,5S,6R,7S,8S,10S,11S,13R,16S)-8-bromo-7-hydroxy-7-(hydroxymethyl)-11,15,18,18-tetramethyl-3,12-dioxo-10-{[(2,2,2-trichloroethoxy)carbonyl]oxy}-16-{[tris(propan-2-yl)silyl]oxy}-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadec-14-en-13-yl acetate→Allyl(bromo)magnesium

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