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CAS 19093-51-7

pent-1-yn-1-ylcopper

Codes:MISO-004

Application context (from source-drug indications)

终止妊娠米非司酮/米索前列醇

Source drugs (routes using this intermediate)

DrugTierExpiry
米非司酮/米索前列醇Mifepristone/MisoprostolTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

米非司酮/米索前列醇原研路线steps: 5total yield: /
4-methyloct-1-yn-4-ol→trimethyl((4-methyloct-1-yn-4-yl)oxy)silane→(E)-((1-iodo-4-methyloct-1-en-4-yl)oxy)trimethylsilane→pent-1-yn-1-ylcopper→methyl 7-((1R,4S)-2-oxo-4-((tetrahydro-2H-pyran-2-yl)oxy)cyclopentyl)heptanoate→methyl 7-((1R,4S)-2-oxo-4-((tetrahydro-2H-pyran-2-yl)oxy)cyclopentyl)heptanoate→methyl 7-((1R,2R,3R)-2-((E)-4-methyl-4-((trimethylsilyl)oxy)oct-1-en-1-yl)-5-oxo-3-((tetrahydro-2H-pyran-2-yl)oxy)cyclopentyl)heptanoate

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