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CAS 195388-53-5
[[(1R)-4-Bromo-1,2-dihydronaphthalen-1-yl]oxy](tert-butyl)diphenylsilane
Codes：Sertraline Hydrochloride-028
Application context (from source-drug indications)
强迫性障碍枸橼酸舍曲林
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 枸橼酸舍曲林Sertraline Citrate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(1R)-1,2-dihydronaphthalen-1-ol→tert-Butyl[(1R)-1,2-dihydronaphthalen-1-yloxy]diphenylsilane→[[(1R)-4-Bromo-1,2-dihydronaphthalen-1-yl]oxy](tert-butyl)diphenylsilane→(3,4-Dichlorophenyl)(trimethyl)stannane→3,4-Dichlorophenol→3,4-Dichlorophenyl trifluoromethanesulfonate→tert-Butyl[[(1R)-4-(3,4-dichlorophenyl)-1,2-dihydronaphthalen-1-yl]oxy]diphenylsilane→(3,4-Dichlorophenyl)boronic acid→(1R)-4-(3,4-Dichlorophenyl)-1,2-dihydronaphthalen-1-ol→(1R,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-ol→(1S,4S)-1-Azido-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalene→4(S)-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1(S)-amine→Carbonochloridic acid ethyl ester→Ethyl [(1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamate→(1S,4S)-4-(3,4-Dichlorophenyl)-N-methyltetralin-1-amine
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