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CAS 198904-85-7
tert-butyl 2-(4-(pyridin-2-yl)benzyl)hydrazine-1-carboxylate
Codes：ATAZ-007
Application context (from source-drug indications)
HIV感染硫酸阿扎那韦/考比司他
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 硫酸阿扎那韦/考比司他Atazanavir Sulfate/Cobicistat | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
4-bromobenzaldehyde→1-bromo-4-(dimethoxymethyl)benzene→2-bromopyridine→4-(pyridin-2-yl)benzaldehyde→tert-butyl hydrazinecarboxylate→tert-butyl (E)-2-(4-(pyridin-2-yl)benzylidene)hydrazine-1-carboxylate→tert-butyl 2-(4-(pyridin-2-yl)benzyl)hydrazine-1-carboxylate→tert-butyl ((S)-1-((R)-oxiran-2-yl)-2-phenylethyl)carbamate→tert-butyl 2-((2S,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutyl)-2-(4-(pyridin-2-yl)benzyl)hydrazine-1-carboxylate→(2S,3S)-3-amino-4-phenyl-1-(1-(4-(pyridin-2-yl)benzyl)hydrazinyl)butan-2-ol→(S)-2-((methoxycarbonyl)amino)-3,3-dimethylbutanoic acid
2-bromopyridine→4-(pyridin-2-yl)benzaldehyde→tert-butyl hydrazinecarboxylate→tert-butyl (E)-2-(4-(pyridin-2-yl)benzylidene)hydrazine-1-carboxylate→tert-butyl 2-(4-(pyridin-2-yl)benzyl)hydrazine-1-carboxylate→tert-butyl ((S)-1-((R)-oxiran-2-yl)-2-phenylethyl)carbamate→tert-butyl 2-((2S,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutyl)-2-(4-(pyridin-2-yl)benzyl)hydrazine-1-carboxylate→(2S,3S)-3-amino-4-phenyl-1-(1-(4-(pyridin-2-yl)benzyl)hydrazinyl)butan-2-ol→(S)-2-((methoxycarbonyl)amino)-3,3-dimethylbutanoic acid→(4-formylphenyl)boronic acid→tert-butyl ((2S,3R)-3,4-dihydroxy-1-phenylbutan-2-yl)carbamate→(6R,7S)-7-benzyl-2,2,3,3,11,11-hexamethyl-9-oxo-4,10-dioxa-8-aza-3-siladodecan-6-yl methanesulfonate→(2R,3S)-3-((tert-butoxycarbonyl)amino)-1-hydroxy-4-phenylbutan-2-yl methanesulfonate
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