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CAS 2097133-32-7
Methyl 1-methoxy-4-[4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]cyclohexane-1-carboxylate
Codes：(XIII)1024528-1-b、(VII)1024528-2-a
Application context (from source-drug indications)
非小细胞肺癌普拉替尼甲状腺瘤普拉替尼甲状腺髓样癌普拉替尼
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 普拉替尼Pralsetinib | Tier C — Watch / trade | 2031 |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
Methyl 4-(4-chloro-6-methylpyrimidin-2-yl)-1-methoxycyclohexane-1-carboxylate→3-Amino-5-methylpyrazole→Methyl 1-methoxy-4-[4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]cyclohexane-1-carboxylate→1-Methoxy-4-[4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]cyclohexane-1-carboxylic acid→1-[6-(4-Fluoro-1H-pyrazol-1-yl)pyridin-3-yl]ethan-1-one→1-(6-Bromopyridin-3-yl)ethan-1-one→(1S)-1-[6-(4-Fluoro-1H-pyrazol-1-yl)pyridin-3-yl]ethan-1-amine hydrogen chloride→(1S)-1-[6-(4-Fluoro-1H-pyrazol-1-yl)pyridin-3-yl]ethan-1-amine→(1S)-1-[6-(4-Fluoro-1H-pyrazol-1-yl)pyridin-3-yl]ethan-1-amine hydrogen chloride (1/2)→4-Fluoro-1H-pyrazole→1,1,3,3-Tetrakis(methyloxy)propane→(R)-(+)-2-Methyl-2-propanesulfinamide→(SR)-N-[(1S)-1-[6-(4-Fluoro-1H-pyrazol-1-yl)pyridin-3-yl]ethyl]-2-methylpropane-2-sulfinamide
2-Chloro-6-methylpyrimidin-4-amine→tert-Butyl (2-chloro-6-methylpyrimidin-4-yl)carbamate→Methyl 4-iodo-1-methoxycyclohexane-1-carboxylate→Methyl 4-[4-[(tert-butoxycarbonyl)amino]-6-methylpyrimidin-2-yl]-1-methoxycyclohexane-1-carboxylate→Methyl 1-methoxy-4-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)cyclohexane-1-carboxylate→3-Amino-1-Boc-5-methyl-1H-pyrazole→Methyl 1-methoxy-4-[4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]cyclohexane-1-carboxylate→(1S)-1-[6-(4-Fluoro-1H-pyrazol-1-yl)pyridin-3-yl]ethan-1-amine
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