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CAS 2102429-29-6

3-(N'-Hydroxycarbamimidoyl)-1-oxidopyridin-1-ium

Codes: (I)320339-4-a

Application context (from source-drug indications)

C型尼曼匹克病Arimoclomol Citrate包涵体肌炎Arimoclomol CitrateIII 型戈谢病Arimoclomol CitrateI 型戈谢病Arimoclomol CitrateAmyotrophic lateral sclerosisArimoclomol Citrate

Source drugs (routes using this intermediate)

DrugTierExpiry
Arimoclomol CitrateTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Arimoclomol CitrateOptimised routesteps: 5total yield: /
3-(N'-Hydroxycarbamimidoyl)-1-oxidopyridin-1-ium→2-Hydroxy-4-azaspiro[3.5]nonan-4-ylium chloride→3-{N'-[2-Hydroxy-3-(piperidin-1-yl)propoxy]carbamimidoyl}-1-oxidopyridin-1-ium→3-[1-Chloro-1-[2-hydroxy-3-(1-piperidinyl)propoxyiminomethyl]pyridine 1-oxide→(2R,3R)-2,3-Bis(benzoyloxy)butanedioic acid N-[(2R)-2-hydroxy-3-(piperidin-1-yl)propoxy]-1-oxo-1lambda5-pyridine-3-carboximidoyl chloride→N-[(2R)-2-Hydroxy-3-(piperidin-1-yl)propoxy]-1-oxo-1lambda5-pyridine-3-carboximidoyl chloride

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