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CAS 2171277-86-2

(2S,5R,6R)-6-[[(2R)-2-([[(9H-Fluoren-9-yl)methoxy]carbonyl]amino)-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

Codes:Amoxicillin-029

Application context (from source-drug indications)

幽门螺杆菌感染阿莫西林/奥美拉唑/利福布汀消化不良阿莫西林/奥美拉唑/利福布汀十二指肠溃疡雷贝拉唑钠/甲硝唑/阿莫西林特发性血小板减少性紫癜雷贝拉唑钠/甲硝唑/阿莫西林胃溃疡雷贝拉唑钠/甲硝唑/阿莫西林胃炎雷贝拉唑钠/甲硝唑/阿莫西林幽门螺杆菌感染雷贝拉唑钠/甲硝唑/阿莫西林边缘带B细胞淋巴瘤克拉霉素/雷贝拉唑钠/阿莫西林十二指肠溃疡克拉霉素/雷贝拉唑钠/阿莫西林特发性血小板减少性紫癜克拉霉素/雷贝拉唑钠/阿莫西林胃溃疡克拉霉素/雷贝拉唑钠/阿莫西林胃炎克拉霉素/雷贝拉唑钠/阿莫西林幽门螺杆菌感染克拉霉素/雷贝拉唑钠/阿莫西林

Source drugs (routes using this intermediate)

DrugTierExpiry
阿莫西林/奥美拉唑/利福布汀Amoxicillin/Omeprazole/RifabutinTier C — Watch / trade-
雷贝拉唑钠/甲硝唑/阿莫西林Rabeprazole Sodium/Metronidazole/AmoxicillinTier C — Watch / trade-
克拉霉素/雷贝拉唑钠/阿莫西林Clarithromycin/Rabeprazole Sodium/AmoxicillinTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

阿莫西林/奥美拉唑/利福布汀优化路线steps: 3total yield: /
(2R)-2-Amino-2-(4-hydroxyphenyl)acetic acid→(2R)-([[(9H-Fluoren-9-yl)methoxy]carbonyl]amino)(4-hydroxyphenyl)acetic acid→(+)-6-Aminopenicillanic acid→(2S,5R,6R)-6-[[(2R)-2-([[(9H-Fluoren-9-yl)methoxy]carbonyl]amino)-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
雷贝拉唑钠/甲硝唑/阿莫西林优化路线steps: 3total yield: /
(2R)-2-Amino-2-(4-hydroxyphenyl)acetic acid→(2R)-([[(9H-Fluoren-9-yl)methoxy]carbonyl]amino)(4-hydroxyphenyl)acetic acid→(+)-6-Aminopenicillanic acid→(2S,5R,6R)-6-[[(2R)-2-([[(9H-Fluoren-9-yl)methoxy]carbonyl]amino)-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
克拉霉素/雷贝拉唑钠/阿莫西林优化路线steps: 3total yield: /
(2R)-2-Amino-2-(4-hydroxyphenyl)acetic acid→(2R)-([[(9H-Fluoren-9-yl)methoxy]carbonyl]amino)(4-hydroxyphenyl)acetic acid→(+)-6-Aminopenicillanic acid→(2S,5R,6R)-6-[[(2R)-2-([[(9H-Fluoren-9-yl)methoxy]carbonyl]amino)-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

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