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CAS 21881-77-6
Dimethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Codes：Lercanidipine Hydrochloride-041
Application context (from source-drug indications)
原发性高血压缬沙坦/盐酸乐卡地平
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 缬沙坦/盐酸乐卡地平Valsartan/Lercanidipine Hydrochloride | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
Dimethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate→2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid
(3-Nitrophenyl)methanone→1-Methoxybutane-1,3-dione→(Z)-Methyl 3-aminobut-2-enoate→Dimethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate→(+/-)-5-(Methoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3-pyridinecarboxylic acid→1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-ol→1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-yl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate→5-(Chlorocarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid methyl ester→(3,3-Diphenylpropyl)(methyl)amine→1-Chloro-2-methyl-2-propanol
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