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CAS 21900-41-4
5-bromo-2-methylbenzoyl chloride
Codes：CANA-002
Application context (from source-drug indications)
终末期肾脏病卡格列净/盐酸二甲双胍心脏和血管疾病卡格列净/盐酸二甲双胍腹主动脉瘤卡格列净/盐酸二甲双胍二型糖尿病卡格列净/盐酸二甲双胍
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 卡格列净/盐酸二甲双胍Canagliflozin/Metformin Hydrochloride | Tier B — Position early | 2029 |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
5-bromo-2-methylbenzoic acid→5-bromo-2-methylbenzoyl chloride→2-(4-fluorophenyl)thiophene→(5-bromo-2-methylphenyl)(5-(4-fluorophenyl)thiophen-2-yl)methanone→2-(5-bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene→(3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one→(3R,4S,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol→(3R,4S,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol
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