CAS 219780-44-6

(1S,2S,9R,10R)-9-(benzyloxy)-1,2-dihydroxy-12,15,15-trimethyl-10-(phenylsulfanyl)tricyclo[9.3.1.0(3,8)]pentadeca-3,7,11-trien-13-one

Codes：(IV)101438-24-a

Application context (from source-drug indications)

乳腺癌Paclitaxel/Encequidar mesylate腺癌Paclitaxel/Encequidar mesylate血管肉瘤Paclitaxel/Encequidar mesylate实体瘤Paclitaxel/Encequidar mesylate

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Paclitaxel/Encequidar mesylatePaclitaxel/Encequidar mesylate	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Paclitaxel/Encequidar mesylate优化路线steps: 14total yield: /

(1S,2S,3S,5S,9S,13S,18S)-2,3-dihydroxy-6,19,19-trimethyl-5-[(tributylsilyl)oxy]-10,12-dioxapentacyclo[7.7.2.1(3,7).0(1,18).0(13,18)]nonadec-6-ene-11,16-dione→(1S,2S,4S,6S,8S,12S,13S,14S)-12,14-dihydroxy-9,19,19-trimethyl-4-phenyl-8-[(tributylsilyl)oxy]-3,5-dioxapentacyclo[11.4.1.1(6,10).0(1,13).0(2,6)]nonadec-9-en-17-one→(1S,2S,6S,8S,12S,14S,16S,21S)-4,4-di-tert-butyl-9,22,22-trimethyl-14-phenyl-8-[(tributylsilyl)oxy]-3,5,13,15-tetraoxa-4-silahexacyclo[10.7.2.1(6,10).0(1,21).0(2,6).0(16,21)]docos-9-en-19-one→(1S,2S,9R,10R)-9-(benzyloxy)-1,2-dihydroxy-12,15,15-trimethyl-10-(phenylsulfanyl)tricyclo[9.3.1.0(3,8)]pentadeca-3,7,11-trien-13-one→(1S,3S,5S,10S,11S,12S,16S)-11,15,18,18-tetramethyl-3-phenyl-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadeca-6,14-diene-7,10,12,16-tetrol→(1S,3S,5S,6R,10S,11S,12S,16S)-10,12,16-trihydroxy-11,15,18,18-tetramethyl-3-phenyl-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadec-14-en-7-one→(1S,3S,5S,6R,10S,11S,16S)-10-[(2-methoxypropan-2-yl)oxy]-11,15,18,18-tetramethyl-3-phenyl-16-[(tributylsilyl)oxy]-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadec-14-ene-7,12-dione→(1S,3S,5S,6R,7S,10R,12S,13S,15R,18S)-7-hydroxy-13,17,20,20-tetramethyl-14-oxo-3-phenyl-18-[(tributylsilyl)oxy]-12-[(triethylsilyl)oxy]-2,4,9-trioxapentacyclo[14.3.1.0(1,5).0(6,13).0(7,10)]icos-16-en-15-yl acetate→(1S,3S,5S,6S,10S,11S,16S)-10-[(2-methoxypropan-2-yl)oxy]-11,15,18,18-tetramethyl-3-phenyl-16-[(tributylsilyl)oxy]-7-[(trimethylsilyl)methyl]-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadeca-7,14-dien-12-one→(1S,3S,5S,6S,8S,10S,11S,13R,16S)-8-chloro-10-[(2-methoxypropan-2-yl)oxy]-11,15,18,18-tetramethyl-7-methylidene-12-oxo-3-phenyl-16-[(tributylsilyl)oxy]-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadec-14-en-13-yl acetate→(1S,3S,5S,6S,8S,10S,11S,16S)-8-chloro-10-[(2-methoxypropan-2-yl)oxy]-11,15,18,18-tetramethyl-7-methylidene-3-phenyl-16-[(tributylsilyl)oxy]-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadec-14-en-12-one→(1S,5S,12R,13R,16S)-12-(benzyloxy)-3,3-di-tert-butyl-15,18,18-trimethyl-13-(phenylsulfanyl)-16-[(tributylsilyl)oxy]-2,4-dioxa-3-silatetracyclo[12.3.1.0(1,5).0(6,11)]octadeca-6,10,14-triene→(1S,5Z)-1-hydroxy-4,6,6-trimethyl-5-[(phenylsulfanyl)methylidene]-3-{[tris(propan-2-yl)silyl]oxy}cyclohex-3-ene-1-carbaldehyde→(2S,6S,8S,12S,16S,19R)-4,4-di-tert-butyl-9,21,21-trimethyl-14-phenyl-8-[(tributylsilyl)oxy]-3,5,13,15-tetraoxa-4-silapentacyclo[10.7.1.1(6,10).0(2,6).0(16,20)]henicosa-1(20),9-dien-19-ol→{[(4S,5S,9E)-4-{6-[bis(benzyloxy)methyl]cyclohexa-1,5-dien-1-yl}-2,8,10,10-tetramethyl-9-[(phenylsulfanyl)methylidene]-1,3-dioxa-2-boraspiro[4.5]dec-7-en-7-yl]oxy}tris(propan-2-yl))silane→{6-[bis(benzyloxy)methyl]cyclohexa-1,5-dien-1-yl}lithium

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