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CAS 219909-83-8
3-((2S,4S)-4-mercaptopyrrolidine-2-carboxamido)benzoic acid hydrochloride
Codes: ERTA-021, ERTA-029
Application context (from source-drug indications)
Complicated skin and skin structure infectionErtapenem SodiumIntra-abdominal infectionErtapenem SodiumBacteraemiaErtapenem SodiumUrinary tract infectionErtapenem SodiumCommunity-acquired pneumoniaErtapenem SodiumPyelonephritisErtapenem Sodium
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Ertapenem Sodium | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
4-nitrobenzyl (4R,5R,6S)-3-((diphenoxyphosphoryl)oxy)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate→3-((2S,4S)-4-mercaptopyrrolidine-2-carboxamido)benzoic acid hydrochloride→1,1,3,3-tetramethylguanidine 3-((2S,4S)-4-(((4R,5S,6S)-6-((R)-1-hydroxyethyl)-4-methyl-2-(((4-nitrobenzyl)oxy)carbonyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl)thio)pyrrolidine-2-carboxamido)benzoate
(2S,4R)-1-(diisopropoxyphosphoryl)-4-hydroxypyrrolidine-2-carboxylic acid→(2S,4R)-1-(diisopropoxyphosphoryl)-4-hydroxypyrrolidine-2-carboxylic diphenylphosphinic anhydride→(2S,4R)-1-(diisopropoxyphosphoryl)-4-((methylsulfonyl)oxy)pyrrolidine-2-carboxylic diphenylphosphinic anhydride→diisopropyl ((1S,4S)-3-oxo-2-thia-5-azabicyclo[2.2.1]heptan-5-yl)phosphonate→3-aminobenzoic acid→3-((2S,4S)-1-(diisopropoxyphosphoryl)-4-mercaptopyrrolidine-2-carboxamido)benzoic acid→3-((2S,4S)-4-mercaptopyrrolidine-2-carboxamido)benzoic acid hydrochloride
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