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CAS 2231630-58-1

4-[(Dimethylamino)methylidene]-2-methyl-1,3-oxazol-5(4H)-one

Codes:Ramipril-017

Application context (from source-drug indications)

高胆固醇血症阿托伐他汀钙/雷米普利高血压阿托伐他汀钙/雷米普利

Source drugs (routes using this intermediate)

DrugTierExpiry
阿托伐他汀钙/雷米普利Atorvastatin Calcium Hydrate/RamiprilTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

阿托伐他汀钙/雷米普利优化路线steps: 8total yield: 65g(Ramipril-010)
(2S,3aS,6aS)-Octahydrocyclopenta[b]pyrrole-2-carboxylic acid hydrochloride→2-Acetamidoacetic acid→Formyldimethylamine→4-[(Dimethylamino)methylidene]-2-methyl-1,3-oxazol-5(4H)-one→Sodium (2-methyl-5-oxo-1,3-oxazol-4(5H)-ylidene)methanolate→(2-Methyl-5-oxo-1,3-oxazol-4(5H)-ylidene)methyl acetate→4-(Ethoxymethylidene)-2-phenyl-1,3-oxazol-5(4H)-one→2-(Phenylformamido)Acetic Acid→(Diethoxymethoxy)ethane→1-Morpholinocyclopentene→2-Methyl-4-[[2-(morpholin-4-yl)cyclopent-1-en-1-yl]methylidene]-1,3-oxazol-5(4H)-one→4-[[2-(Morpholin-4-yl)cyclopent-1-en-1-yl]methylidene]-2-phenyl-1,3-oxazol-5(4H)-one→Methyl 2-benzamido-3-[2-(morpholin-4-yl)cyclopent-1-en-1-yl]prop-2-enoate→Methyl 2-acetamido-3-[2-(morpholin-4-yl)cyclopent-1-en-1-yl]prop-2-enoate→Methyl N-benzoyl-3-[2-(morpholin-4-yl)cyclopent-1-en-1-yl]-L-alaninate→Methyl N-acetyl-3-[2-(morpholin-4-yl)cyclopent-1-en-1-yl]-L-alaninate

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