← Back to patent-cliff list
CAS 223734-59-6
(((1S,6S)-1-(2-allyl-3-methoxyphenyl)-6-((tetrahydro-2H-pyran-2-yl)oxy)undec-2-yn-1-yl)oxy)(tert-butyl)dimethylsilane
Codes: TREP-041
Application context (from source-drug indications)
Interstitial lung diseaseTreprostinilPulmonary hypertensionTreprostinilPulmonary arterial hypertensionTreprostinilIdiopathic pulmonary fibrosisTreprostinilPulmonary fibrosisTreprostinilIdiopathic pulmonary arterial hypertensionTreprostinil
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Treprostinil | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(3aS,9aS)-5-methoxy-1-((3S)-3-((tetrahydro-2H-pyran-2-yl)oxy)octyl)-1,3,3a,4,9,9a-hexahydro-2H-cyclopenta[b]naphthalen-2-one→(1R,2R,3aS,9aS)-1-((S)-3-hydroxyoctyl)-5-methoxy-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-2-ol→(1R,2R,3aS,9aS)-1-((S)-3-hydroxyoctyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalene-2,5-diol→2-(((1R,2R,3aS,9aS)-2-hydroxy-1-((S)-3-hydroxyoctyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-5-yl)oxy)acetonitrile→(3-methoxyphenyl)methanol→tert-butyl((3-methoxybenzyl)oxy)dimethylsilane→3-bromoprop-1-ene→((2-allyl-3-methoxybenzyl)oxy)(tert-butyl)dimethylsilane→(2-allyl-3-methoxyphenyl)methanol→2-allyl-3-methoxybenzaldehyde→2-(((S)-dec-1-yn-5-yl)oxy)tetrahydro-2H-pyran→(6S)-1-(2-allyl-3-methoxyphenyl)-6-((tetrahydro-2H-pyran-2-yl)oxy)undec-2-yn-1-ol→(6S)-1-(2-allyl-3-methoxyphenyl)-6-((tetrahydro-2H-pyran-2-yl)oxy)undec-2-yn-1-one→(R)-diphenyl(pyrrolidin-2-yl)methanol→(1S,6S)-1-(2-allyl-3-methoxyphenyl)-6-((tetrahydro-2H-pyran-2-yl)oxy)undec-2-yn-1-ol→(((1S,6S)-1-(2-allyl-3-methoxyphenyl)-6-((tetrahydro-2H-pyran-2-yl)oxy)undec-2-yn-1-yl)oxy)(tert-butyl)dimethylsilane→(4R,9aS)-4-((tert-butyldimethylsilyl)oxy)-8-methoxy-3-((3S)-3-((tetrahydro-2H-pyran-2-yl)oxy)octyl)-1,4,9,9a-tetrahydro-2H-cyclopenta[b]naphthalen-2-one→(1R,2R,3aS,9aS)-5-methoxy-1-((3S)-3-((tetrahydro-2H-pyran-2-yl)oxy)octyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-2-ol
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications |
|---|---|---|---|---|---|
| Qualified Partner — East China API Works | (1R,2R,3aS,9aS)-2,3,3a,4,9,9a-Hexahydro-1-[(3S)-3-hydroxyoctyl]-1H-benz[f]indene-2,5-diol Pharmaceutical Intermediates | On request | On request | On request | — |
| Unibest Nantong cGMP Site | 1-broMo-5-fluoro-2-Methyl-3-nitrobenzene Pharmaceutical Intermediates | On request | On request | On request | — |
| Unibest Taizhou GMP-like Site | methyl 4-cyclopropyl-2-fluorobenzoate Pharmaceutical Intermediates | On request | On request | On request | — |
| Qualified Partner — East China API Works | tert-butyl 2-(4-amino-6-chloropyrimidin-5-yloxy)ethylmethylcarbamate Pharmaceutical Intermediates | On request | On request | On request | — |
| Unibest Nantong cGMP Site | 2H-Benz[f]inden-2-one, 9-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3,3a,4,9-tetrahydro-5-methoxy-1-[(3S)-3-[(tetrahydro-2H-pyran-2-yl)oxy]octyl]-, (3aS,9R)- Pharmaceutical Intermediates | On request | On request | On request | — |
| Unibest Taizhou GMP-like Site | 2-allyl-3-methoxybenzaldehyde Pharmaceutical Intermediates | On request | On request | On request | — |
| Qualified Partner — East China API Works | (5S)-1-Decyn-5-ol Pharmaceutical Intermediates | On request | On request | On request | — |
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.