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CAS 2307735-30-2

1,1,1-Trifluoro-N-(4-oxo-1,2,3,4-tetrahydronaphthalen-1-yl)methanesulfonamide

Codes:Sertraline Hydrochloride-168

Application context (from source-drug indications)

强迫性障碍枸橼酸舍曲林

Source drugs (routes using this intermediate)

DrugTierExpiry
枸橼酸舍曲林Sertraline CitrateTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

枸橼酸舍曲林优化路线steps: 9total yield: /
4-Benzylbutyric acid→1,3-Dioxo-2,3-dihydro-1H-isoindol-2-yl 5-phenylpentanoate→1,2,3,4-Tetrahydronaphthalene→1-Oxotetralin→1,1,1-Trifluoro-N-methyl-N-(4-oxo-1,2,3,4-tetrahydronaphthalen-1-yl)methanesulfonamide→Iodomethane→1,1,1-Trifluoro-N-(4-oxo-1,2,3,4-tetrahydronaphthalen-1-yl)methanesulfonamide→4-[Methyl(trifluoromethanesulfonyl)amino]-3,4-dihydronaphthalen-1-yl trifluoromethanesulfonate→(3,4-Dichlorophenyl)boronic acid→N-[4-(3,4-Dichlorophenyl)-1,2-dihydronaphthalen-1-yl]-1,1,1-trifluoro-N-methylmethanesulfonamide→N-[(1S,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl]-1,1,1-trifluoro-N-methylmethanesulfonamide→(1S,4S)-4-(3,4-Dichlorophenyl)-N-methyltetralin-1-amine

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