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CAS 23115-42-6

Ethyl 2-acetamidoacrylate

Codes:Ramipril-059

Application context (from source-drug indications)

高胆固醇血症阿托伐他汀钙/雷米普利高血压阿托伐他汀钙/雷米普利

Source drugs (routes using this intermediate)

DrugTierExpiry
阿托伐他汀钙/雷米普利Atorvastatin Calcium Hydrate/RamiprilTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

阿托伐他汀钙/雷米普利优化路线steps: 5total yield: 19.67g(Ramipril-008)
2-Oxopropionic acid ethyl ester→Acetamide→Benzamide→Ethyl 2-acetamidoacrylate→Ethyl 2-(benzoylamino)acrylate→1-Morpholinocyclopentene→1-(1-Cyclopentenyl)pyrrolidine→Cyclopentanone→Ethyl N-acetyl-3-(2-oxocyclopentyl)alaninate→Ethyl N-benzoyl-3-(2-oxocyclopentyl)alaninate→Benzyl (2S,3aS,6aS)-octahydrocyclopenta[b]pyrrole-2-carboxylate hydrochloride

Intermediates available on this site

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