CAS 2348367-88-2

1'-Benzyl-1',2',3',6'-tetrahydro[3,4'-bipyridin]-6-amine

Codes: Dalpiciclib Isethionate-006

Application context (from source-drug indications)

Breast cancerDalpiciclib IsethionateMetastatic breast cancerDalpiciclib IsethionateProstate cancerDalpiciclib Isethionate三阴性乳腺癌Dalpiciclib IsethionateMeningiomaDalpiciclib IsethionateHepatic function declineDalpiciclib Isethionate

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Dalpiciclib Isethionate	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

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Dalpiciclib IsethionateProcess routesteps: 8total yield: 707g(Dalpiciclib Isethionate (Free))

1-Benzylpiperidin-4-one→4-Methylbenzenesulfonhydrazide→N'-(1-Benzylpiperidin-4-ylidene)-4-methylbenzene-1-sulfonohydrazide→5-Bromo-2-(2,5-dimethyl-1H-pyrrol-1-yl)pyridine→1'-Benzyl-6-(2,5-dimethyl-1H-pyrrol-1-yl)-1',2',3',6'-tetrahydro-3,4'-bipyridine→1'-Benzyl-1',2',3',6'-tetrahydro[3,4'-bipyridin]-6-amine→5-(Piperidin-4-yl)pyridin-2-amine→tert-Butyl 4-(6-aminopyridin-3-yl)piperidine-1-carboxylate→6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7-one→tert-Butyl 4-[6-[(6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino]pyridin-3-yl]piperidine-1-carboxylate

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