CAS 239088-22-3

(9H-fluoren-9-yl)methyl decyl(2-oxoethyl)carbamate

Codes：TELA-003

Application context (from source-drug indications)

呼吸机相关性肺炎盐酸替拉凡星细菌性肺炎盐酸替拉凡星医院获得性肺炎盐酸替拉凡星医疗保健相关性肺炎盐酸替拉凡星复杂皮肤和皮肤结构感染盐酸替拉凡星葡萄球菌感染盐酸替拉凡星

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
盐酸替拉凡星Telavancin Hydrochloride	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

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盐酸替拉凡星原研路线steps: 5total yield: 3.05 g

2-(decylamino)ethan-1-ol→(9H-fluoren-9-yl)methyl decyl(2-hydroxyethyl)carbamate→(9H-fluoren-9-yl)methyl decyl(2-oxoethyl)carbamate→Vancomycin→Vancomycin, N3''-[2-[decyl[(9H-fluoren-9-ylmethoxy)carbonyl]amino]ethyl]-→Vancomycin, N3''-[2-(decylamino)ethyl]-→(aminomethyl)phosphonic acid

盐酸替拉凡星优化路线steps: 3total yield: /

(9H-fluoren-9-yl)methyl decyl(2-oxoethyl)carbamate→Vancomycin→(aminomethyl)phosphonic acid→Vancomycin, N3''-[2-[decyl[(9H-fluoren-9-ylmethoxy)carbonyl]amino]ethylidene]-→Vancomycin, N3''-[2-[decyl[(9H-fluoren-9-ylmethoxy)carbonyl]amino]ethylidene]-29-[[(phosphonomethyl)amino]methyl]-

盐酸替拉凡星优化路线steps: 4total yield: /

(9H-fluoren-9-yl)methyl decyl(2-oxoethyl)carbamate→Vancomycin→Vancomycin, N3''-[2-[decyl[(9H-fluoren-9-ylmethoxy)carbonyl]amino]ethyl]-→(aminomethyl)phosphonic acid→Vancomycin, N3''-[2-[decyl[(9H-fluoren-9-ylmethoxy)carbonyl]amino]ethylidene]-→Vancomycin, N3''-[2-[decyl[(9H-fluoren-9-ylmethoxy)carbonyl]amino]ethyl]-29-[[(phosphonomethyl)amino]methyl]-

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