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CAS 2413947-65-4
(3aS,5S,8S,9aS,10S,12S,13S,13aR,13bS)-5-[[tert-Butyl(dimethyl)silyl]oxy]-10,13-dihydroxy-6,9a,13,14,14-pentamethyl-8-[(triethylsilyl)oxy]-12-[(trimethylsilyl)oxy]-5,8,9,9a,10,11,12,13,13a,13b-decahydro-2H,4H-3a,7-methanobenzo[3,4]cyclodeca[1,2-d][1,3]dioxol-2-one
Codes：(XXVI)101438-68-b
Application context (from source-drug indications)
乳腺癌Paclitaxel/Encequidar mesylate腺癌Paclitaxel/Encequidar mesylate血管肉瘤Paclitaxel/Encequidar mesylate实体瘤Paclitaxel/Encequidar mesylate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Paclitaxel/Encequidar mesylatePaclitaxel/Encequidar mesylate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(4alpha,5alpha,6alpha,10beta,13alpha)-13-[[tert-Butyl(dimethyl)silyl]oxy]-1,4-dihydroxy-10-[(triethylsilyl)oxy]-5,6-epoxytax-11-en-2-one→(1S,5S,6R,7S,8S,10S,11R,13R,16S)-10-[(benzyloxy)methyl]-16-[(tert-butyldimethylsilyl)oxy]-7-hydroxy-7-(hydroxymethyl)-11,15,18,18-tetramethyl-3-oxo-13-[(triethylsilyl)oxy]-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadec-14-en-8-yl methanesulfonate→(2beta,4alpha,10beta,13alpha)-10-[(Triethylsilyl)oxy](2-~2~H)taxa-5,11-diene-2,4,13-triol→(2beta,4alpha,10beta,13alpha)-13-[[tert-Butyl(dimethyl)silyl]oxy]-10-[(triethylsilyl)oxy](2-~2~H)taxa-5,11-diene-1,2,4-triol→(2beta,4alpha,5alpha,6alpha,10beta,13alpha)-13-[[tert-Butyl(dimethyl)silyl]oxy]-10-[(triethylsilyl)oxy](2-~2~H)-5,6-epoxytax-11-ene-1,2,4-triol→(3aS,5S,8S,9aR,10S,12S,13aS,13bS)-10-[(Benzyloxy)methyl]-5-[[tert-butyl(dimethyl)silyl]oxy]-12-hydroxy-6,9a,14,14-tetramethyl-13-methylidene-8-[(triethylsilyl)oxy]-5,8,9,9a,10,11,12,13,13a,13b-decahydro-2H,4H-3a,7-methanobenzo[3,4]cyclodeca[1,2-d][1,3]dioxol-2-one→(3aS,5S,8S,9aR,10S,12S,13S,13aR,13bS)-10-[(Benzyloxy)methyl]-5-[[tert-butyl(dimethyl)silyl]oxy]-13-hydroxy-6,9a,13,14,14-pentamethyl-8-[(triethylsilyl)oxy]-12-[(trimethylsilyl)oxy]-5,8,9,9a,10,11,12,13,13a,13b-decahydro-2H,4H-3a,7-methanobenzo[3,4]cyclodeca[1,2-d][1,3]dioxol-2-one→(3aS,5S,8S,9aS,10R,11R,12S,13S,13aR,13bS)-5-[[tert-Butyl(dimethyl)silyl]oxy]-13-hydroxy-6,9a,13,15,15-pentamethyl-8-[(triethylsilyl)oxy]-12-[(trimethylsilyl)oxy]-5,8,9,9a,10,11,12,13,13a,13b-decahydro-2H,4H-10,11-epoxy-3a,7-methanobenzo[3,4]cyclodeca[1,2-d][1,3]dioxol-2-one→(3aS,5S,8S,9aS,10S,12S,13S,13aR,13bS)-5-[[tert-Butyl(dimethyl)silyl]oxy]-10,13-dihydroxy-6,9a,13,14,14-pentamethyl-8-[(triethylsilyl)oxy]-12-[(trimethylsilyl)oxy]-5,8,9,9a,10,11,12,13,13a,13b-decahydro-2H,4H-3a,7-methanobenzo[3,4]cyclodeca[1,2-d][1,3]dioxol-2-one→(3aS,5S,8S,9aS,11S,12S,13S,13aR,13bS)-5-[[tert-Butyl(dimethyl)silyl]oxy]-13-hydroxy-6,9a,13,15,15-pentamethyl-8-[(triethylsilyl)oxy]-5,8,9,9a,10,11,12,13,13a,13b-decahydro-2H,4H-11,12-epoxy-3a,7-methanobenzo[3,4]cyclodeca[1,2-d][1,3]dioxol-2-one
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