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CAS 2413947-75-6
(3R,4S)-1-Benzoyl-3-(benzyloxy)-4-phenylazetidin-2-one
Codes：(XXXV)101438-68-c
Application context (from source-drug indications)
乳腺癌Paclitaxel/Encequidar mesylate腺癌Paclitaxel/Encequidar mesylate血管肉瘤Paclitaxel/Encequidar mesylate实体瘤Paclitaxel/Encequidar mesylate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Paclitaxel/Encequidar mesylatePaclitaxel/Encequidar mesylate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(1S,5S,6R,7S,8S,10S,11R,13R,16S)-10-[(benzyloxy)methyl]-16-[(tert-butyldimethylsilyl)oxy]-7-hydroxy-7-(hydroxymethyl)-11,15,18,18-tetramethyl-3-oxo-13-[(triethylsilyl)oxy]-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadec-14-en-8-yl methanesulfonate→(3aS,5S,9aR,10S,11aR,13aS,13bR,13cS)-10-[(Benzyloxy)methyl]-5-[[tert-butyl(dimethyl)silyl]oxy]-13a-hydroxy-6,9a,14,14-tetramethyl-4,5,9a,10,11,11a,13,13a,13b,13c-decahydro-2H-3a,7-methano[1,3]dioxolo[9,10]cyclodeca[1,2-d][1]benzoxete-2,8(9H)-dione→(2alpha,5beta,7beta,10beta,13alpha)-7-[(Benzyloxy)methyl]-13-[[tert-butyl(dimethyl)silyl]oxy]-1,2,4,10-tetrahydroxy-5,20-epoxytax-11-en-9-one→(3aS,5S,8R,9aR,10S,11aR,13aS,13bR,13cS)-10-[(Benzyloxy)methyl]-5-[[tert-butyl(dimethyl)silyl]oxy]-6,9a,14,14-tetramethyl-2,9-dioxo-4,5,8,9,9a,10,11,11a,13b,13c-decahydro-2H-3a,7-methano[1,3]dioxolo[9,10]cyclodeca[1,2-d][1]benzoxete-8,13a(13H)-diyl diacetate→Lithiumbenzene→(2alpha,5beta,7beta,10beta,13alpha)-4,10-Bis(acetyloxy)-7-[(benzyloxy)methyl]-1,13-dihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate→(3R,4S)-1-Benzoyl-3-(benzyloxy)-4-phenylazetidin-2-one→(2alpha,5beta,7beta,10beta,13alpha)-4,10-Bis(acetyloxy)-13-[[(2R,3S)-3-benzamido-2-(benzyloxy)-3-phenylpropanoyl]oxy]-7-[(benzyloxy)methyl]-1-hydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
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