CAS 24228-40-8

ethyl 1-benzylpiperidine-4-carboxylate

Codes：DONE-003

Application context (from source-drug indications)

阿尔茨海默病盐酸美金刚/盐酸多奈哌齐

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
盐酸美金刚/盐酸多奈哌齐Memantine Hydrochloride/Donepezil Hydrochloride	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

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盐酸美金刚/盐酸多奈哌齐原研路线steps: 5total yield: 0.36 g

ethyl piperidine-4-carboxylate→(chloromethyl)benzene→ethyl 1-benzylpiperidine-4-carboxylate→(1-benzylpiperidin-4-yl)methanol→1-benzylpiperidine-4-carbaldehyde→5,6-dimethoxy-2,3-dihydro-1H-inden-1-one→(E)-2-((1-benzylpiperidin-4-yl)methylene)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one

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