Unibest 优贝德
← Back to patent-cliff list

CAS 24590-49-6

(2S)-1-Hydroxypropan-2-yl methanesulfonate

Codes：Tenofovir disoproxil phosphate-035

Application context (from source-drug indications)

HIV感染拉米夫定/富马酸替诺福韦二吡呋酯慢性乙型肝炎拉米夫定/富马酸替诺福韦二吡呋酯HIV感染依非韦伦/拉米夫定/富马酸替诺福韦二吡呋酯HIV感染恩曲他滨/盐酸利匹韦林/富马酸替诺福韦二吡呋酯

Source drugs (routes using this intermediate)

DrugTierExpiry
拉米夫定/富马酸替诺福韦二吡呋酯Lamivudine/Tenofovir Disoproxil FumarateTier C — Watch / trade-
依非韦伦/拉米夫定/富马酸替诺福韦二吡呋酯Efavirenz/Lamivudine/Tenofovir Disoproxil FumarateTier C — Watch / trade-
恩曲他滨/盐酸利匹韦林/富马酸替诺福韦二吡呋酯Emtricitabine/Rilpivirine Hydrochloride/Tenofovir Disoproxil FumarateTier B — Position early-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

拉米夫定/富马酸替诺福韦二吡呋酯优化路线steps: 8total yield: 1.97g(Tenofovir disoproxil phosphate-013)
2(R)-Methyloxirane→(R)-1,2-Propanediol→2(S)-Hydroxypropionic acid→Methyl (2S)-2-hydroxypropanoate→Methyl (2S)-2-[(methanesulfonyl)oxy]propanoate→(2S)-1-Hydroxypropan-2-yl methanesulfonate→(2R)-2-Hydroxypropanoic acid→D-Lactic acid methyl ester→(2R)-2-Hydroxypropyl 4-methylbenzene-1-sulfonate
依非韦伦/拉米夫定/富马酸替诺福韦二吡呋酯优化路线steps: 8total yield: 1.97g(Tenofovir disoproxil phosphate-013)
2(R)-Methyloxirane→(R)-1,2-Propanediol→2(S)-Hydroxypropionic acid→Methyl (2S)-2-hydroxypropanoate→Methyl (2S)-2-[(methanesulfonyl)oxy]propanoate→(2S)-1-Hydroxypropan-2-yl methanesulfonate→(2R)-2-Hydroxypropanoic acid→D-Lactic acid methyl ester→(2R)-2-Hydroxypropyl 4-methylbenzene-1-sulfonate
恩曲他滨/盐酸利匹韦林/富马酸替诺福韦二吡呋酯优化路线steps: 8total yield: 1.97g(Tenofovir disoproxil phosphate-013)
2(R)-Methyloxirane→(R)-1,2-Propanediol→2(S)-Hydroxypropionic acid→Methyl (2S)-2-hydroxypropanoate→Methyl (2S)-2-[(methanesulfonyl)oxy]propanoate→(2S)-1-Hydroxypropan-2-yl methanesulfonate→(2R)-2-Hydroxypropanoic acid→D-Lactic acid methyl ester→(2R)-2-Hydroxypropyl 4-methylbenzene-1-sulfonate

Intermediates available on this site

No listed intermediates for this target yet — send an RFQ directly and it will enter our matching pool.

This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.