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CAS 24939-24-0
4-aminobenzenesulfonyl chloride
Codes：DARU-030
Application context (from source-drug indications)
HIV感染乙醇达芦那韦/利托那韦HIV感染乙醇达芦那韦/考比司他
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 乙醇达芦那韦/利托那韦Darunavir Ethanolate/Ritonavir | Tier C — Watch / trade | - |
| 乙醇达芦那韦/考比司他Darunavir Ethanolate/Cobicistat | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol→2-methylpropan-1-amine→butane-1,4-diol→(9H-fluoren-9-yl)methyl (4-hydroxybutyl) carbonate→(9H-fluoren-9-yl)methyl (4-oxobutyl) carbonate→(9H-fluoren-9-yl)methyl (2-oxoethyl) carbonate→(2S,3S)-3-amino-1-chloro-4-phenylbutan-2-ol hydrochloride→(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate→(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ((2S,3R)-3-hydroxy-4-(isobutylamino)-1-phenylbutan-2-yl)carbamate→4-aminobenzenesulfonyl chloride
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol→2-methylpropan-1-amine→butane-1,4-diol→(9H-fluoren-9-yl)methyl (4-hydroxybutyl) carbonate→(9H-fluoren-9-yl)methyl (4-oxobutyl) carbonate→(9H-fluoren-9-yl)methyl (2-oxoethyl) carbonate→(2S,3S)-3-amino-1-chloro-4-phenylbutan-2-ol hydrochloride→(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate→(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ((2S,3R)-3-hydroxy-4-(isobutylamino)-1-phenylbutan-2-yl)carbamate→4-aminobenzenesulfonyl chloride
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