CAS 26391-06-0

2-cyano-N,N-diethylacetamide

Codes: ENTA-002

Application context (from source-drug indications)

Parkinson's diseaseEntacapone立位耐力不良EntacaponeTachycardiaEntacaponeObesityEntacapone

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Entacapone	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

EntacaponeOriginator routesteps: 1total yield: 2.23 g

3,4-dihydroxy-5-nitrobenzaldehyde→2-cyano-N,N-diethylacetamide→1-(piperidin-1-yl)ethanone

EntacaponeOptimised routesteps: 4total yield: 105.00 mg

2-cyano-N,N-diethylacetamide→3,4-dimethoxy-5-nitrobenzoic acid→3,4-dimethoxy-5-nitrobenzoyl chloride→(Z)-2-cyano-3-(3,4-dimethoxy-5-nitrophenyl)-N,N-diethyl-3-hydroxyacrylamide→(E)-2-cyano-3-(3,4-dimethoxy-5-nitrophenyl)-N,N-diethylacrylamide

EntacaponeOptimised routesteps: 3total yield: 9.45 g

3,4-dihydroxy-5-nitrobenzaldehyde→2-cyano-N,N-diethylacetamide→2-cyanoacetic acid→4-hydroxy-3-methoxy-5-nitrobenzaldehyde

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