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CAS 267884-84-4
tert-Butyl [(1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamate
Codes：Sertraline Hydrochloride-055
Application context (from source-drug indications)
强迫性障碍枸橼酸舍曲林
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 枸橼酸舍曲林Sertraline Citrate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
methyl (2R)-2-(dibenzylamino)-2-phenylacetate→(2R)-2-(dibenzylamino)-2-phenylethanol→(2R)-2-(dibenzylamino)-2-phenylacetaldehyde→(Carbethoxymethylene)triphenylphosphorane→ethyl (2E,4S)-4-(dibenzylamino)-4-phenylbut-2-enoate→methyl (4S)-4-(dibenzylamino)-4-phenylbutanoate→(4S)-4-(dibenzylamino)-4-phenylbutan-1-ol→(4S)-4-(dibenzylamino)-4-phenylbutanal→3,4-Dichlorophenylmagnesium bromide→(4S)-4-(dibenzylamino)-1-(3,4-dichlorophenyl)-4-phenylbutan-1-ol→(1S,4S)-N,N-dibenzyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-amine→tert-Butyl [(1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamate→tert-butyl N-[(1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl]-N-methylcarbamate
2-Ethenylbenzaldehyde→(R)-(+)-2-Methyl-2-propanesulfinamide→N-[(E)-(2-Ethenylphenyl)methylidene]-2-methylpropane-2-sulfinamide→Allyl(bromo)zinc→N-[(1S)-1,2-Dihydronaphthalen-1-yl]-2-methylpropane-2-sulfinamide→(1S)-1,2-Dihydronaphthalen-1-amine→tert-Butyl (1S)-1,2-dihydronaphthalen-1-ylcarbamate→tert-Butyl [(1S)-4-bromo-1,2-dihydronaphthalen-1-yl]carbamate→(3,4-Dichlorophenyl)boronic acid→tert-Butyl [(1S)-4-(3,4-dichlorophenyl)-1,2-dihydronaphthalen-1-yl]carbamate→tert-Butyl [(1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamate
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