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CAS 272439-89-1
(1S,5E)-1-[(S)-{6-[bis(benzyloxy)methyl]cyclohexa-1,5-dien-1-yl}(hydroxy)methyl]-4,6,6-trimethyl-5-[(phenylsulfanyl)methylidene]-3-[(triisopropylsilyl)oxy]cyclohex-3-en-1-ol
Codes：(XVI)101438-35-a
Application context (from source-drug indications)
乳腺癌Paclitaxel/Encequidar mesylate腺癌Paclitaxel/Encequidar mesylate血管肉瘤Paclitaxel/Encequidar mesylate实体瘤Paclitaxel/Encequidar mesylate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Paclitaxel/Encequidar mesylatePaclitaxel/Encequidar mesylate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2-(2-Propynyloxy)tetrahydropyran→Methyl acetaldehyde→6-(oxan-2-yloxy)hex-4-yn-3-ol→(4Z)-6-(oxan-2-yloxy)hex-4-en-3-ol→5-(hydroxymethyl)-2,4,4-trimethyl-3-oxocyclohex-1-en-1-yl 2,2-dimethylpropanoate→(4Z)-6-(oxan-2-yloxy)hex-4-en-3-one→lithium(1+) ion 1-ethoxy-2-methylprop-1-en-1-olate→ethyl 2,2-dimethyl-3-[(oxan-2-yloxy)methyl]-5-oxoheptanoate→2,4,4-trimethyl-5-[(oxan-2-yloxy)methyl]-3-oxocyclohex-1-en-1-yl 2,2-dimethylpropanoate→5-formyl-2,4,4-trimethyl-3-oxocyclohex-1-en-1-yl 2,2-dimethylpropanoate→(5E)-2,4,4-trimethyl-3-oxo-5-{[(triisopropylsilyl)oxy]methylidene}cyclohex-1-en-1-yl 2,2-dimethylpropanoate→(5S)-5-formyl-5-hydroxy-2,4,4-trimethyl-3-oxocyclohex-1-en-1-yl 2,2-dimethylpropanoate→(1S)-1-hydroxy-4,6,6-trimethyl-5-oxo-3-[(triisopropylsilyl)oxy]cyclohex-3-ene-1-carbaldehyde→(1S,5Z)-1-hydroxy-4,6,6-trimethyl-5-[(phenylsulfanyl)methylidene]-3-{[tris(propan-2-yl)silyl]oxy}cyclohex-3-ene-1-carbaldehyde→(1S,5S,12R,13R)-12-(benzyloxy)-3,3-di-tert-butyl-15,18,18-trimethyl-13-(phenylsulfanyl)-2,4-dioxa-3-silatetracyclo[12.3.1.0(1,5).0(6,11)]octadeca-6,10,14-trien-16-one→{[(benzyloxy)(6-bromocyclohexa-1,5-dien-1-yl)methoxy]methyl}benzene→(1S,5E)-1-[(S)-{6-[bis(benzyloxy)methyl]cyclohexa-1,5-dien-1-yl}(hydroxy)methyl]-4,6,6-trimethyl-5-[(phenylsulfanyl)methylidene]-3-[(triisopropylsilyl)oxy]cyclohex-3-en-1-ol→{[(4S,5S,9E)-4-{6-[bis(benzyloxy)methyl]cyclohexa-1,5-dien-1-yl}-2,8,10,10-tetramethyl-9-[(phenylsulfanyl)methylidene]-1,3-dioxa-2-boraspiro[4.5]dec-7-en-7-yl]oxy}tris(propan-2-yl))silane→(1S,5S,12R,13R)-12-(benzyloxy)-3,15,18,18-tetramethyl-13-(phenylsulfanyl)-2,4-dioxa-3-boratetracyclo[12.3.1.0(1,5).0(6,11)]octadeca-6,10,14-trien-16-one→(1S,5S,12R,13R,16S)-12-(benzyloxy)-3,3-di-tert-butyl-16-[(tert-butyldimethylsilyl)oxy]-15,18,18-trimethyl-13-(phenylsulfanyl)-2,4-dioxa-3-silatetracyclo[12.3.1.0(1,5).0(6,11)]octadeca-6,10,14-triene→(1S,5S,7R,10S,12S,16S)-12-(benzyloxy)-3,3-di-tert-butyl-16-[(tert-butyldimethylsilyl)oxy]-15,18,18-trimethyl-2,4-dioxa-3-silatetracyclo[12.3.1.0(1,5).0(6,11)]octadeca-6(11),14-diene-7,10-diol
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