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CAS 2766607-29-6

(6E)-7-(3,3,7,7,9-Pentamethyl-1,5-dioxaspiro[5.5]undec-8-en-8-yl)hept-6-en-1-ol

Codes:(IV)101438-73-a

Application context (from source-drug indications)

乳腺癌Paclitaxel/Encequidar mesylate腺癌Paclitaxel/Encequidar mesylate血管肉瘤Paclitaxel/Encequidar mesylate实体瘤Paclitaxel/Encequidar mesylate

Source drugs (routes using this intermediate)

DrugTierExpiry
Paclitaxel/Encequidar mesylatePaclitaxel/Encequidar mesylateTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Paclitaxel/Encequidar mesylate优化路线steps: 10total yield: /
Hept-6-yn-1-ol→7-(Tributylstannyl)hept-6-en-1-ol→3,3,7,7,9-Pentamethyl-1,5-dioxaspiro[5.5]undec-8-en-8-yl trifluoromethanesulfonate→(6E)-7-(3,3,7,7,9-Pentamethyl-1,5-dioxaspiro[5.5]undec-8-en-8-yl)hept-6-en-1-ol→3-[(1E)-Hepta-1,6-dien-1-yl]-2,2,4-trimethyl-1-[(trimethylsilyl)oxy]cyclohex-3-ene-1-carbaldehyde→8-[(1E)-7-Iodohept-1-en-1-yl]-3,3,7,7,9-pentamethyl-1,5-dioxaspiro[5.5]undec-8-ene→8-[Hepta-1,6-dien-1-yl]-3,3,7,7,9-pentamethyl-1,5-dioxaspiro[5.5]undec-8-ene→3-[(1E)-Hepta-1,6-dien-1-yl]-2,2,4-trimethylcyclohex-3-en-1-one→3-[(1E)-Hepta-1,6-dien-1-yl]-2,2,4-trimethyl-1-[(trimethylsilyl)oxy]cyclohex-3-ene-1-carbonitrile→N'-(2-Ethenyl-2-methylcyclohexylidene)-2,4,6-tri(propan-2-yl)benzene-1-sulfonohydrazide→(R)-(6-Ethenyl-6-methylcyclohex-1-en-1-yl)[(1R)-3-[(1E)-hepta-1,6-dien-1-yl]-2,2,4-trimethyl-1-[(trimethylsilyl)oxy]cyclohex-3-en-1-yl]methanol→(1S)-1-[(S)-(6-Ethenyl-6-methylcyclohex-1-en-1-yl)(hydroxy)methyl]-3-[(1E)-hepta-1,6-dien-1-yl]-2,2,4-trimethylcyclohex-3-en-1-ol→(4S,5S)-4-(6-Ethenyl-6-methylcyclohex-1-en-1-yl)-7-[(1E)-hepta-1,6-dien-1-yl]-6,6,8-trimethyl-1,3-dioxaspiro[4.5]dec-7-en-2-one

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