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CAS 289038-78-4
1-Benzothiepin-4-ol, 3,3-dibutyl-5-[4-[[4-(chloromethyl)phenyl]methoxy]phenyl]-7-(dimethylamino)-2,3,4,5-tetrahydro-, 1,1-dioxide, (4R,5R)
Codes: Lopix-014
Application context (from source-drug indications)
PruritusMaralixibat Chloride进行性家族性肝内胆汁淤积症Maralixibat ChlorideAlagille综合征Maralixibat Chloride胆汁淤积Maralixibat ChlorideLiver diseaseMaralixibat Chloride肝内胆汁淤积Maralixibat Chloride
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Maralixibat Chloride | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
diethyl 2,2-dibutylmalonate→2,2-dibutylpropane-1,3-diol→1,3,2-Dioxathiane, 5,5-dibutyl-, 2-oxide→1,3,2-Dioxathiane, 5,5-dibutyl-, 2,2-dioxide→4-fluoro-2-(4-methoxybenzyl)benzenethiol→2-butyl-2-((4-fluoro-2-(4-methoxybenzyl)phenylthio)methyl)hexan-1-ol→2-butyl-2-((4-fluoro-2-(4-methoxybenzyl)phenylsulfinyl)methyl)hexan-1-ol→2-butyl-2-((4-fluoro-2-(4-methoxybenzyl)phenylsulfinyl)methyl)hexanal→1-Benzothiepin-4-ol, 3,3-dibutyl-7-fluoro-2,3,4,5-tetrahydro-5-(4-methoxyphenyl)-, 1-oxide, (4R,5R)→1-Benzothiepin-4-ol, 3,3-dibutyl-7-fluoro-2,3,4,5-tetrahydro-5-(4-methoxyphenyl)-, 1,1-dioxide, (4R,5R)→1-Benzothiepin-4-ol, 3,3-dibutyl-7-(dimethylamino)-2,3,4,5-tetrahydro-5-(4-methoxyphenyl)-, 1,1-dioxide, (4R,5R)-rel→1-Benzothiepin-4-ol, 3,3-dibutyl-7-(dimethylamino)-2,3,4,5-tetrahydro-5-(4-hydroxyphenyl)-, 1,1-dioxide, (4R,5R)→1,4-bis(chloromethyl)benzene→1-Benzothiepin-4-ol, 3,3-dibutyl-5-[4-[[4-(chloromethyl)phenyl]methoxy]phenyl]-7-(dimethylamino)-2,3,4,5-tetrahydro-, 1,1-dioxide, (4R,5R)→4-fluorophenol→1-(chloromethyl)-4-methoxybenzene→4-fluoro-2-(4-methoxybenzyl)phenol→dimethylcarbamothioic chloride→O-4-fluoro-2-(4-methoxybenzyl)phenyl dimethylcarbamothioate
1-Benzothiepin-4-ol, 3,3-dibutyl-7-(dimethylamino)-2,3,4,5-tetrahydro-5-(4-methoxyphenyl)-, 1,1-dioxide, (4R,5R)-rel→1-Benzothiepin-4-ol, 3,3-dibutyl-7-(dimethylamino)-2,3,4,5-tetrahydro-5-(4-hydroxyphenyl)-, 1,1-dioxide, (4R,5R)→1,4-bis(chloromethyl)benzene→1-Benzothiepin-4-ol, 3,3-dibutyl-5-[4-[[4-(chloromethyl)phenyl]methoxy]phenyl]-7-(dimethylamino)-2,3,4,5-tetrahydro-, 1,1-dioxide, (4R,5R)→5-chloro-2-nitrobenzoic acid→anisole→(2-chloro-5-nitrophenyl)(4-methoxyphenyl)methanone→1-chloro-2-(4-methoxybenzyl)-4-nitrobenzene→2-butyl-2-((2-(4-methoxybenzyl)-4-nitrophenylthio)methyl)hexanal→2-butyl-2-((2-(4-methoxybenzyl)-4-nitrophenylsulfonyl)methyl)hexanal→2-((4-amino-2-(4-methoxybenzyl)phenylsulfonyl)methyl)-2-butylhexanal→benzyl 4-(2-butyl-2-formylhexylsulfonyl)-3-(4-methoxybenzyl)phenylcarbamate→Lopix-028→Lopix-029
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