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CAS 30163-03-2

(S)-2-hydroxy-3-mercaptopropanoic acid

Codes：LAMI-010

Application context (from source-drug indications)

HIV感染多替拉韦/拉米夫定/艾酚福韦HIV感染拉米夫定/富马酸替诺福韦二吡呋酯慢性乙型肝炎拉米夫定/富马酸替诺福韦二吡呋酯HIV感染依非韦伦/拉米夫定/富马酸替诺福韦二吡呋酯

Source drugs (routes using this intermediate)

DrugTierExpiry
多替拉韦/拉米夫定/艾酚福韦Dolutegravir/Lamivudine/Tenofovir AlafenamideTier C — Watch / trade-
拉米夫定/富马酸替诺福韦二吡呋酯Lamivudine/Tenofovir Disoproxil FumarateTier C — Watch / trade-
依非韦伦/拉米夫定/富马酸替诺福韦二吡呋酯Efavirenz/Lamivudine/Tenofovir Disoproxil FumarateTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

多替拉韦/拉米夫定/艾酚福韦优化路线steps: 4total yield: /
2-oxoethyl benzoate→((2R,5S)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl)methyl benzoate→(S)-2-hydroxy-3-mercaptopropanoic acid→(2R,5S)-2-((benzoyloxy)methyl)-1,3-oxathiolane-5-carboxylic acid→((2R)-5-acetoxy-1,3-oxathiolan-2-yl)methyl benzoate
拉米夫定/富马酸替诺福韦二吡呋酯优化路线steps: 4total yield: /
2-oxoethyl benzoate→((2R,5S)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl)methyl benzoate→(S)-2-hydroxy-3-mercaptopropanoic acid→(2R,5S)-2-((benzoyloxy)methyl)-1,3-oxathiolane-5-carboxylic acid→((2R)-5-acetoxy-1,3-oxathiolan-2-yl)methyl benzoate
依非韦伦/拉米夫定/富马酸替诺福韦二吡呋酯优化路线steps: 4total yield: /
2-oxoethyl benzoate→((2R,5S)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl)methyl benzoate→(S)-2-hydroxy-3-mercaptopropanoic acid→(2R,5S)-2-((benzoyloxy)methyl)-1,3-oxathiolane-5-carboxylic acid→((2R)-5-acetoxy-1,3-oxathiolan-2-yl)methyl benzoate

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