CAS 312-84-5

D-serine

Codes：LACO-001

Application context (from source-drug indications)

强直阵挛性癫痫拉考沙胺癫痫拉考沙胺癫痫部分性发作拉考沙胺癫痫发作拉考沙胺

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
拉考沙胺Lacosamide	Tier B — Position early	2028

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

拉考沙胺原研路线steps: 3total yield: 2 g

D-serine→acetyl-D-serine→(R)-2-acetamido-N-benzyl-3-hydroxypropanamide

拉考沙胺优化路线steps: 5total yield: 50 g

D-serine→(chloromethanetriyl)tribenzene→trityl-D-serine→phenylmethanamine→(R)-N-benzyl-3-hydroxy-2-(tritylamino)propanamide→(R)-N-benzyl-3-methoxy-2-(tritylamino)propanamide→(R)-2-amino-N-benzyl-3-methoxypropanamide

Intermediates available on this site

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