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CAS 319472-91-8
(E)-6-iodo-3-styryl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazole
Codes：AXIT-014
Application context (from source-drug indications)
肾细胞癌阿昔替尼神经内分泌瘤阿昔替尼腺样囊性癌阿昔替尼副神经节瘤阿昔替尼嗜铬细胞瘤阿昔替尼导管癌阿昔替尼
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 阿昔替尼Axitinib | Tier B — Position early | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
6-nitro-1H-indazole→3-iodo-6-nitro-1H-indazole→3-iodo-6-nitro-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazole→(E)-styrylboronic acid→(E)-6-nitro-3-styryl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazole→(E)-3-styryl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-6-amine→(E)-6-iodo-3-styryl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazole→6-iodo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazole-3-carbaldehyde→triphenyl(pyridin-2-ylmethyl)phosphonium chloride→(E)-6-iodo-3-(2-(pyridin-2-yl)vinyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazole→methyl 2-mercaptobenzoate→methyl (E)-2-((3-(2-(pyridin-2-yl)vinyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-6-yl)thio)benzoate→(E)-2-((3-(2-(pyridin-2-yl)vinyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-6-yl)thio)benzoic acid→(E)-N-methyl-2-((3-(2-(pyridin-2-yl)vinyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-6-yl)thio)benzamide
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications |
|---|---|---|---|---|---|
| Unibest Nantong cGMP Site | 6-Iodo-1H-indazole Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Taizhou GMP-like Site | (E)-6-Iodo-3-[2-(pyridin-2-yl)ethenyl]-1-(tetrahydro-2H-pyran-2-yl)- 1H-indazole Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.