CAS 32018-96-5

1-benzyl-4-methylpiperidin-3-one

Codes：TOFA-001

Application context (from source-drug indications)

强直性脊柱炎枸橼酸托法替布幼年型类风湿性关节炎枸橼酸托法替布溃疡性结肠炎枸橼酸托法替布银屑病关节炎枸橼酸托法替布类风湿关节炎枸橼酸托法替布

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
枸橼酸托法替布Tofacitinib Citrate	Tier B — Position early	2028

Position in synthesis routes (up/downstream chain)

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枸橼酸托法替布原研路线steps: 4total yield: /

1-benzyl-4-methylpiperidin-3-one→1-benzyl-N,4-dimethylpiperidin-3-amine→4-chloro-7H-pyrrolo[2,3-d]pyrimidine→N-(1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine→N-methyl-N-(4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine→2-cyanoacetyl chloride

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Supplier	Product	Price band	MOQ	Lead time	Qualifications
Qualified Partner — East China API Works	1-benzyl-4-methylpiperidin-3-one Pharmaceutical Intermediates	询价	询价	询价	—

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