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CAS 320347-97-5

(1S,3R,4S)-quinuclidin-3-yl 2-hydroxy-2,2-di(thiophen-2-yl)acetate

Codes:ACLI-005

Application context (from source-drug indications)

慢性阻塞性肺疾病阿地溴铵/富马酸福莫特罗

Source drugs (routes using this intermediate)

DrugTierExpiry
阿地溴铵/富马酸福莫特罗Aclidinium Bromide/Formoterol Fumarate DihydrateTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

阿地溴铵/富马酸福莫特罗原研路线steps: 3total yield: 7.2 g
dimethyl oxalate→2-bromothiophene→methyl 2-hydroxy-2,2-di(thiophen-2-yl)acetate→(R)-quinuclidin-3-ol→(1S,3R,4S)-quinuclidin-3-yl 2-hydroxy-2,2-di(thiophen-2-yl)acetate→(3-bromopropoxy)benzene

Intermediates available on this site

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