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CAS 3355-28-0
1-bromobut-2-yne
Codes：LINA-002
Application context (from source-drug indications)
二型糖尿病利格列汀
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 利格列汀Linagliptin | Tier C — Watch / trade | 2029 |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
8-bromo-3-methyl-3,7-dihydro-1H-purine-2,6-dione→1-bromobut-2-yne→8-bromo-7-(but-2-yn-1-yl)-3-methyl-3,7-dihydro-1H-purine-2,6-dione→2-(chloromethyl)-4-methylquinazoline→8-bromo-7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-3,7-dihydro-1H-purine-2,6-dione→(R)-tert-butyl piperidin-3-ylcarbamate→tert-butyl (R)-(1-(7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)piperidin-3-yl)carbamate
8-bromo-3-methyl-3,7-dihydro-1H-purine-2,6-dione→1-bromobut-2-yne→8-bromo-7-(but-2-yn-1-yl)-3-methyl-3,7-dihydro-1H-purine-2,6-dione→2-(chloromethyl)-4-methylquinazoline→8-bromo-7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-3,7-dihydro-1H-purine-2,6-dione→(R)-piperidin-3-amine dihydrochloride
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications |
|---|---|---|---|---|---|
| Unibest Taizhou GMP-like Site | 3-Methylxanthine Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Qualified Partner — East China API Works | 8-Bromo-3-methyl-3,9-dihydro-1H-purine-2,6-dione Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Nantong cGMP Site | 8-Bromo-7-(but-2-yn-1-yl)-3-methyl-3,7-dihydro-1H-purine-2,6-dione Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Taizhou GMP-like Site | 2-(Chloromethyl)-4-methylquinazoline Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Qualified Partner — East China API Works | 8-Bromo-7-(but-2-yn-1-yl)-3-methy1-1-[(4-methylquinazolin-2-yl)methyl]-3,7-dihydro-1H-purine-2,6-dione Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Nantong cGMP Site | [(3R)-1-[7-(2-Butynyl)-2,3,6,7-tetrahydro-3-methy1-1-[(4-methy1-2-quinazolinyl)methyl]-2,6-dioxo-1H-purin-8-yll-3-piperidinyllcarbamicacid 1,1-dimethylethyl ester Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.