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CAS 343312-15-2
Methyl(1R,2S,3S,5S)-3-(4-bromophenyl)-8-(3-fluoropropyl)-8-azabicyclo[3.2.1]octane-2-carboxylate
Codes: Ioflupane (123I)-015
Application context (from source-drug indications)
Lewy body dementiaIoflupane (123I)Diagnostic agentIoflupane (123I)ParkinsonismIoflupane (123I)Alzheimer's diseaseIoflupane (123I)Parkinson's diseaseIoflupane (123I)DementiaIoflupane (123I)
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Ioflupane (123I) | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
8-Methyl-8-azabicyclo[3.2.1]octan-3-one→Carbonicaciddimethyldiester→Hydroxymethane→Methyl8-methyl-3-oxo-8-azabicyclo[3.2.1]octane-2-carboxylate→Methyl3-hydroxy-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate→Methyl8-methyl-8-azabicyclo[3.2.1]oct-2-ene-2-carboxylate→1,4-Dibromobenzene→(±)-Methyl(1R*,2S*,3S*,5S*)-3-(4-bromophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate→(±)-Methyl(1R*,2S*,3S*,5S*)-3-(4-bromophenyl)-8-azabicyclo[3.2.1]octane-2-carboxylate→1-Bromo-3-fluoropropane→Methyl(1R,2S,3S,5S)-3-(4-bromophenyl)-8-(3-fluoropropyl)-8-azabicyclo[3.2.1]octane-2-carboxylate→Methyl(1R,2S,3S,5S)-8-(3-fluoropropyl)-3-[4-(trimethylstannyl)phenyl]-8-azabicyclo[3.2.1]octane-2-carboxylate
Intermediates available on this site
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