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CAS 365997-32-6
ethyl (1S,3R,4R)-3-azido-4-hydroxycyclohexane-1-carboxylate
Codes：EDOX-005
Application context (from source-drug indications)
肺栓塞甲苯磺酸艾多沙班静脉血栓栓塞甲苯磺酸艾多沙班中风甲苯磺酸艾多沙班栓塞甲苯磺酸艾多沙班静脉血栓形成甲苯磺酸艾多沙班缺血性卒中甲苯磺酸艾多沙班
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 甲苯磺酸艾多沙班Edoxaban Tosilate Hydrate | Tier B — Position early | 2028 |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
cyclohex-3-ene-1-carboxylic acid→(S)-cyclohex-3-ene-1-carboxylic acid→(1S,4S,5S)-4-iodo-6-oxabicyclo[3.2.1]octan-7-one→ethyl (1S,3S,6R)-7-oxabicyclo[4.1.0]heptane-3-carboxylate→ethyl (1S,3R,4R)-3-azido-4-hydroxycyclohexane-1-carboxylate→ethyl (1S,3R,4R)-3-((tert-butoxycarbonyl)amino)-4-hydroxycyclohexane-1-carboxylate→ethyl (1S,3R,4S)-4-azido-3-((tert-butoxycarbonyl)amino)cyclohexane-1-carboxylate→(1S,3R,4S)-4-azido-3-((tert-butoxycarbonyl)amino)cyclohexane-1-carboxylic acid→tert-butyl ((1R,2S,5S)-2-azido-5-(dimethylcarbamoyl)cyclohexyl)carbamate→(1S,3R,4S)-3-amino-4-azido-N,N-dimethylcyclohexane-1-carboxamide→lithium 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylate→N-((1R,2S,5S)-2-azido-5-(dimethylcarbamoyl)cyclohexyl)-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamide→N-((1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl)-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamide→sodium 2-((5-chloropyridin-2-yl)amino)-2-oxoacetate
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