CAS 365998-36-3

tert-butyl ((1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl)carbamate

Codes：EDOX-037

Application context (from source-drug indications)

肺栓塞甲苯磺酸艾多沙班静脉血栓栓塞甲苯磺酸艾多沙班中风甲苯磺酸艾多沙班栓塞甲苯磺酸艾多沙班静脉血栓形成甲苯磺酸艾多沙班缺血性卒中甲苯磺酸艾多沙班

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
甲苯磺酸艾多沙班Edoxaban Tosilate Hydrate	Tier B — Position early	2028

Position in synthesis routes (up/downstream chain)

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甲苯磺酸艾多沙班优化路线steps: 4total yield: /

tert-butyl ((1R,2S,5S)-2-azido-5-(dimethylcarbamoyl)cyclohexyl)carbamate→lithium 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylate→sodium 2-((5-chloropyridin-2-yl)amino)-2-oxoacetate→tert-butyl ((1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl)carbamate→tert-butyl ((1R,2S,5S)-2-(2-((5-chloropyridin-2-yl)amino)-2-oxoacetamido)-5-(dimethylcarbamoyl)cyclohexyl)carbamate→N1-((1S,2R,4S)-2-amino-4-(dimethylcarbamoyl)cyclohexyl)-N2-(5-chloropyridin-2-yl)oxalamide

甲苯磺酸艾多沙班优化路线steps: 5total yield: /

ethyl (1S,3R,4S)-4-azido-3-((tert-butoxycarbonyl)amino)cyclohexane-1-carboxylate→tert-butyl ((1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl)carbamate→ethyl (1S,3R,4S)-4-amino-3-((tert-butoxycarbonyl)amino)cyclohexane-1-carboxylate→ethyl (1S,3R,4S)-4-(((benzyloxy)carbonyl)amino)-3-((tert-butoxycarbonyl)amino)cyclohexane-1-carboxylate→(1S,3R,4S)-4-(((benzyloxy)carbonyl)amino)-3-((tert-butoxycarbonyl)amino)cyclohexane-1-carboxylic acid→benzyl tert-butyl ((1S,2R,4S)-4-(dimethylcarbamoyl)cyclohexane-1,2-diyl)dicarbamate

Intermediates available on this site

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Supplier	Product	Price band	MOQ	Lead time	Qualifications
Qualified Partner — East China API Works	tert-butyl (1R,2S,5S)-2-aMino-5-(diMethylcarbaMoyl)cyclohexylcarbaMate Pharmaceutical Intermediates	询价	询价	询价	—

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