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CAS 380380-60-9
5-bromo-2-(2H-tetrazol-5-yl)pyridine
Codes：TEDI-011
Application context (from source-drug indications)
皮肤和皮肤结构感染泰地唑利磷酸盐葡萄球菌感染泰地唑利磷酸盐细菌性皮肤疾病泰地唑利磷酸盐
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 泰地唑利磷酸盐Tedizolid Phosphate | Tier C — Watch / trade | 2029 |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
3-fluoroaniline→benzyl (3-fluorophenyl)carbamate→(R)-oxiran-2-ylmethyl butyrate→(R)-3-(3-fluorophenyl)-5-(hydroxymethyl)oxazolidin-2-one→(R)-3-(3-fluoro-4-iodophenyl)-5-(hydroxymethyl)oxazolidin-2-one→(R)-3-(3-fluoro-4-(tributylstannyl)phenyl)-5-(hydroxymethyl)oxazolidin-2-one→5-bromo-2-(2-methyl-2H-tetrazol-5-yl)pyridine→(R)-3-(3-fluoro-4-(6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl)phenyl)-5-(hydroxymethyl)oxazolidin-2-one→2,5-dibromopyridine→(5-(methylsulfonyl)pyridin-2-yl)methanamine hydrochloride→5-bromo-2-(2H-tetrazol-5-yl)pyridine
(R)-3-(3-fluoro-4-iodophenyl)-5-(hydroxymethyl)oxazolidin-2-one→5-bromo-2-(2H-tetrazol-5-yl)pyridine→2-fluoro-1-iodo-4-isocyanatobenzene→(R)-oxiran-2-ylmethyl 4-methylbenzenesulfonate→(R)-(3-(3-fluoro-4-iodophenyl)-2-oxooxazolidin-5-yl)methyl methanesulfonate→(R)-(3-(3-fluoro-4-iodophenyl)-2-oxooxazolidin-5-yl)methyl dihydrogen phosphate→(6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl)boronic acid→dimethyl (6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl)boronate
(R)-3-(3-fluoro-4-iodophenyl)-5-(hydroxymethyl)oxazolidin-2-one→(R)-3-(3-fluoro-4-(6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl)phenyl)-5-(hydroxymethyl)oxazolidin-2-one→(5-(methylsulfonyl)pyridin-2-yl)methanamine hydrochloride→5-bromo-2-(2H-tetrazol-5-yl)pyridine→4-bromo-3-fluoroaniline→benzyl (4-bromo-3-fluorophenyl)carbamate→(4-(((benzyloxy)carbonyl)amino)-2-fluorophenyl)boronic acid→benzyl (3-fluoro-4-(6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl)phenyl)carbamate→ammonium 5-(5-bromopyridin-2-yl)tetrazol-2-ide
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