CAS 4085-31-8

4,4'-(Propane-1,3-diyl)bis(piperazin-4,1-diy)bis(7-chloroquinoline)

Codes：Piperaquine Phosphate-006

Application context (from source-drug indications)

疟原虫感染Arterolane maleate/Piperaquine Phosphate

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Arterolane maleate/Piperaquine PhosphateArterolane maleate/Piperaquine Phosphate	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Arterolane maleate/Piperaquine Phosphate优化路线steps: 3total yield: 26.9(Piperaquine Phosphate (API))

4,7-Bis(chloranyl)quinoline→1,4-Diazacyclohexane→7-Chloro-4-(1-piperazinyl)quinoline→7-Chloro-4-(piperazin-1-yl)quinoline hydrogen chloride→1,3-Dibromopropane→4,4'-(Propane-1,3-diyl)bis(piperazin-4,1-diy)bis(7-chloroquinoline)

Intermediates available on this site

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