CAS 417721-36-9

4-chloro-7-methoxyquinoline-6-carboxamide

Codes：LENT-008

Application context (from source-drug indications)

肾细胞癌甲磺酸仑伐替尼子宫内膜癌甲磺酸仑伐替尼肝细胞癌甲磺酸仑伐替尼甲状腺瘤甲磺酸仑伐替尼

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
甲磺酸仑伐替尼Lenvatinib Mesilate	Tier A — Act now	2028

Position in synthesis routes (up/downstream chain)

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甲磺酸仑伐替尼原研路线steps: 9total yield: 22.4 mg

4-amino-2-chlorobenzonitrile→4-amino-2-methoxybenzonitrile→5-(ethoxymethylene)-2,2-dimethyl-1,3-dioxane-4,6-dione→4-(((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)-2-methoxybenzonitrile→7-methoxy-4-oxo-1,4-dihydroquinoline-6-carbonitrile→7-methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylic acid→4-chloro-7-methoxyquinoline-6-carbonyl chloride→4-chloro-7-methoxyquinoline-6-carboxamide→4-amino-3-chlorophenol→4-(4-amino-3-chlorophenoxy)-7-methoxyquinoline-6-carboxamide→phenyl carbonochloridate→phenyl (4-((6-carbamoyl-7-methoxyquinolin-4-yl)oxy)-2-chlorophenyl)carbamate→cyclopropanamine

甲磺酸仑伐替尼工艺路线steps: 4total yield: 7.78 kg

4-chloro-7-methoxyquinoline-6-carboxamide→4-amino-3-chlorophenol→phenyl carbonochloridate→cyclopropanamine→phenyl (2-chloro-4-hydroxyphenyl)carbamate→1-(2-chloro-4-hydroxyphenyl)-3-cyclopropylurea

甲磺酸仑伐替尼优化路线steps: 4total yield: 59.4 g

4-chloro-7-methoxyquinoline-6-carboxamide→4-amino-3-chlorophenol→cyclopropanamine→tert-butyl (2-chloro-4-hydroxyphenyl)carbamate→tert-butyl (4-((6-carbamoyl-7-methoxyquinolin-4-yl)oxy)-2-chlorophenyl)carbamate→4-(4-amino-3-chlorophenoxy)-7-methoxyquinoline-6-carboxamide hydrochloride

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Supplier	Product	Price band	MOQ	Lead time	Qualifications
Qualified Partner — East China API Works	4-Chloro-7-methoxyquinoline -6-carboxamide Pharmaceutical Intermediates	询价	询价	询价	—

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